What did the New York Times say about extraordinary measures?
Extraordinary Measures, based on events in the life of John Crowley and his family, dramatizes the father's quest to find a cure for Pompe disease, a relatively rare genetic condition that afflicts two of his three children.The quest brings into play three powerful, often competing human motives: a father's love for his children, a scientist's pursuit of knowledge and recognition, and …
What is the plot of extraordinary measures?
· The film Extraordinary Measures is based on a true story which follows the journey of a father who is determined to save his young children’s lives. John and Aileen Crowley have three kids, two of which who have a rare genetic disorder called pompe disease. Pompe disease is a rare inherited disorder in which the glycogen in the body is not broken down, and thus the …
Who are the actors in extraordinary measures?
· As scientists work to find new treatments for Pompe disease -- the devastating genetic "villain" that drives the efforts of the main characters in the …
What happens in extraordinary measures?
A drama centered on the efforts of John and Aileen Crowley to find a researcher who might have a cure for their two children's rare genetic disorder. A Portland couple have two children with Pompe disease, a genetic anomaly that kills most before a child's tenth birthday.
What happens at the end of extraordinary measures?
In the end, one of the other drugs is used to stop Pompe from killing John's kids during a sibling trial. Megan is able to sit up in a car seat since she was a toddler. Dr. Stonewall's theory does pan out and he creates his own research company when he cashes a $6 million cheque.
What are the names of the three children in extraordinary measures?
The Crowley family, portrayed in 'Extraordinary Measures,' fought to find cure for Pompe disease. The Crowley family today (above, from left): Megan, Aileen, John, John Jr. and Patrick.
Is Extraordinary Measures based on a true story?
The film is about parents who form a biotechnology company to develop a drug to save the lives of their children, who have a life-threatening disease. The film is based on the true story of John and Aileen Crowley, whose children have Pompe's disease.
What happened to the kids in extraordinary measures?
In real life, the Crowley children were diagnosed with the most severe form in infancy. In the film they were diagnosed later in childhood and might have been expected to have a somewhat milder, but still fatal, form. Stonehill is a composite of scientists, including Dr.
Where can I find the movie Extraordinary Measures?
Streaming on Roku. Extraordinary Measures, a drama movie starring Brendan Fraser, Harrison Ford, and Keri Russell is available to stream now. Watch it on Vudu Movie & TV Store, VUDU or Prime Video on your Roku device.
What is extraordinary measures rated?
PGExtraordinary Measures / MPAA ratingExtraordinary Measures is rated PG by the MPAA for thematic material, language and a mild suggestive moment.
Is there a cure for Pompe disease?
Unfortunately, no cure exists. However, Pompe disease has benefited from the introduction of enzyme replacement therapy (ERT), which, although expensive, is a major therapeutic advance.
What organelle does Pompe disease affect in the cell and how does this disease affect someone's life?
Mutations in the GAA gene prevent acid alpha-glucosidase from breaking down glycogen effectively, which allows this sugar to build up to toxic levels in lysosomes. This buildup damages organs and tissues throughout the body, particularly the muscles, leading to the progressive signs and symptoms of Pompe disease.
What can you tell me about the real Robert Stonehill?
Robert Stonehill doesn't exist in real life. The Pompe cure was developed by Dr. Yuan-Tsong Chen and his colleagues while he was at Duke University. He is now director of the Institute of Biomedical Science in Taiwan.
Is Pompe disease fatal?
Pompe disease is a rare (estimated at 1 in every 40,000 births), inherited and often fatal disorder that disables the heart and skeletal muscles. It is caused by mutations in a gene that makes an enzyme called acid alpha-glucosidase (GAA).
How do you get Pompe disease?
Pompe disease is inherited in an autosomal recessive pattern. Recessive genetic disorders occur when an individual inherits a non-working gene from each parent. If an individual receives one working gene and one non-working gene for the disease, the person will be a carrier for the disease.
Who was the lead investigator of the Chen trials?
One of the birds even flew. Kishnani was the lead investigator of the trials that would take Chen's work out of the lab and into humans. Clinical trials started in 1999 with three frail babies. Today, one of those babies is a healthy, 11-year-old boy who plays baseball and enjoys a normal life.
What is the name of the movie that Duke researchers are working on?
Duke research leads to "Extraordinary Measures" film. When the film Extraordinary Measures debuts on January 22, it will tell the story of one man's quest to obtain treatment for his children who suffer from a rare metabolic disorder called Pompe disease.
Who invented the Pompe treatment?
The real story began 20 years ago at Duke University Medical Center when pediatric geneticist Y.T. Chen , MD, PhD, began work on the first and only life-saving treatment for Pompe. In 2006, the FDA approved the use of Myozyme, which is manufactured and marketed by Genzyme Corporation, based on Duke's research. ...
What is the extraordinary measure?
Extraordinary Measures is a 2010 American medical drama film starring Brendan Fraser, Harrison Ford, and Keri Russell . It was the first film produced by CBS Films, the film division of CBS Corporation, who released the film on January 22, 2010. The film is about parents who form a biotechnology company to develop a drug to save the lives ...
Who made the movie "The Cure"?
Production. Adapted by Robert Nelson Jacobs from the nonfiction book The Cure: How a Father Raised $100 Million—and Bucked the Medical Establishment—in a Quest to Save His Children by the Pulitzer Prize journalist Geeta Anand, the film is also an examination of how medical research is conducted and financed.
Who is Robert Stonehill?
John, an advertising executive, contacts Robert Stonehill ( Harrison Ford ), a researcher in Nebraska who has done innovative research for an enzyme treatment for the rare disease. John and Aileen raise money to help Stonehill's research and the required clinical trials.
Rare diseases and drug discovery don't usually make for Hollywood blockbusters. But today (January 22) a film about a genetic affliction that strikes fewer than 10,000 people worldwide hits movie screens, and it has some serious star power behind it. Harrison Ford and Brendan Fraser head up the cast of Extraordinary Measures, a new movie that may lift Pompe disease from the shadows of obscurity into the spotlight, as the focal point of an inspirational story of paternal love and scientific innov
Jef (an unusual nickname for Jennifer) got her master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses. After four years of diving off the Gulf...
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Storyline
A Portland couple have two children with Pompe disease, a genetic anomaly that kills most before a child's tenth birthday. The husband, John, an advertising executive, contacts Robert Stonehill, a researcher in Nebraska who has done innovative research for an enzyme treatment.
Did you know
This is his first film since Star Wars: Episode VI - Return of the Jedi (1983) where Harrison Ford has not had his name first in the credits.
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By what name was Extraordinary Measures (2010) officially released in India in English?