Reperfusion injury is a serious problem in ischemic stroke therapy, which leads to neuronal damage and intracranial hemorrhage (ICH). A novel free radical scavenger, NSP-116, has anti-oxidative effect and may ameliorate reperfusion injury.
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What is the relationship between free radical damage and hemorrhagic transformation?
Sep 17, 2009 · Beneficial effect of the oxygen free radical scavenger amifostine (WR-2721) on spinal cord ischemia/reperfusion injury in rabbits. Chronidou F(1), Apostolakis E, Papapostolou I, Grintzalis K, Georgiou CD, Koletsis EN, Karanikolas M, Papathanasopoulos P, Dougenis D.
Is edaravone a free radical scavenger?
Abstract. Increasing data suggest that oxygen free radical species play detrimental roles in ischemic diseases. A free radical scavenger capable of inhibiting oxidative injury is expected to become a new drug for the treatment of ischemic diseases such as cerebral ischemia. Edaravon (3-methyl-1-phenyl-2-pyrazolin-5-one), which has been developed as an neuroprotective agent …
How does limb remote ischemic postconditioning reduce ischemia-reperfusion injury?
Reperfusion injury is a serious problem in ischemic stroke therapy, which leads to neuronal damage and intracranial hemorrhage (ICH). A novel free radical scavenger, NSP-116, has anti-oxidative effect and may ameliorate reperfusion injury. The purpose of this study was to investigate the effects of …
Is there a role for oxygen free radicals in ischemic diseases?
Abstract. Reperfusion of ischaemic skeletal muscle may lead to increased vascular permeability, oedema and ultimately muscle necrosis. Oxygen-derived free radicals have been suggested as aetiological factors in reperfusion injury. Amputated rabbit hindlimbs were subjected to 4 h of ischaemia followed by 2 h or reperfusion with Krebs' buffer.
What is a scavenger of free radicals?
A substance, such as an antioxidant, that helps protect cells from the damage caused by free radicals. Free radicals are unstable molecules that are made during normal cell metabolism (chemical changes that take place in a cell). They can build up in cells and cause damage to other molecules.
How does reperfusion injury relate to oxygen radicals?
In the setting of myocardial ischemia and reperfusion with the marked increases in oxygen radical and NO generation, this balance is disrupted resulting in oxidative injury. Ischemic preconditioning markedly decreases subsequent NO generation and there is recent evidence that oxidant formation is also decreased.
How do free radicals cause cell injury?
Free radicals can cause damage to parts of cells such as proteins, DNA, and cell membranes by stealing their electrons through a process called oxidation.Jun 29, 2011
What is the role of free radicals in cell injury?
Free radicals are molecules with only one electron, or an unpaired electron, in their outer orbital. Free radicals have a habit of stealing electrons from any molecule they come across to make themselves stable and it's what causes all the trouble and potentially can cause cellular injury.Nov 26, 2019