The combination of fluticasone and salmeterol
Salmeterol
Salmeterol is used as a long-term treatment to prevent or decrease wheezing and trouble breathing caused by asthma or ongoing lung disease. It should only be used long-term if your asthma symptoms are not controlled by your other asthma medications. Salmeterol must not be used alone to treat asthma. It is also used to prevent asthma brought on by exercise.
Fluticasone-Salmeterol
This product is used to control and prevent symptoms caused by asthma or ongoing lung disease.
What are fluticasone and salmeterol used for?
Fluticasone and salmeterol is a combination of two medicines that are used to help control the symptoms of asthma and improve breathing.
What is the drug Advair Diskus used for?
ADVAIR DISKUS 250/50 is a twice-daily prescription medicine used long term to treat chronic obstructive pulmonary disease (COPD), including chronic bronchitis, emphysema, or both, for better breathing and fewer flare-ups. ADVAIR HFA is not approved for the treatment of COPD.
What is fluticasone Diskus used for?
FLOVENT is a prescription inhaled corticosteroid medicine for the long-term treatment of asthma in people aged 4 years and older. FLOVENT is not used to relieve sudden breathing problems and won't replace a rescue inhaler. FLOVENT does not relieve sudden breathing problems from asthma.
Is Advair Diskus for asthma or COPD?
This product is used to control and prevent symptoms (wheezing and shortness of breath) caused by asthma or ongoing lung disease (chronic obstructive pulmonary disease-COPD, which includes chronic bronchitis and emphysema). It contains 2 medications: fluticasone and salmeterol.
What is salmeterol used for?
Proper Use. Inhaled salmeterol is used to prevent asthma attacks and to treat chronic obstructive pulmonary disease (COPD). It is not used to relieve an asthma attack that has already started. For relief of an asthma attack that has already started, you should use another medicine.
What kind of medicine is Advair?
The combination of fluticasone and salmeterol (Advair HFA, AirDuo Respiclick) is used in children 12 years of age and older. Fluticasone is in a class of medications called steroids. It works by reducing swelling in the airways. Salmeterol is in a class of medications called long-acting beta-agonists (LABAs).
Why are inhaled steroids used to treat asthma and COPD?
Inhaled corticosteroids (ICSs) are used extensively in the treatment of asthma and chronic obstructive pulmonary disease (COPD) due to their broad antiinflammatory effects. They improve lung function, symptoms, and quality of life and reduce exacerbations in both conditions but do not alter the progression of disease.
When do you take Advair?
Advair® Diskus®:For preventing an asthma attack: Adults and children 12 years of age and older—1 inhalation 2 times per day (morning and evening). The doses should be at least 12 hours apart. ... For treatment and prevention of worsening attacks of COPD: Adults—1 inhalation 2 times per day (morning and evening).
Is salmeterol a bronchodilator?
In summary, salmeterol is a safe and effective bronchodilator that is uniquely long-acting. Giving salmeterol twice a day produced results clinically superior to those of albuterol given either regularly (four times a day) or intermittently (as needed), and these results were sustained over a 12-week period.
Is Advair Diskus a bronchodilator?
Advair Diskus (fluticasone and salmeterol oral inhaler) is a combination of a corticosteroid and a beta2-adrenergic bronchodilator used to treat asthma and chronic bronchitis, including COPD associated with chronic bronchitis.
How does Advair help COPD?
Advair (fluticasone / salmeterol) is a combination asthma and COPD medication. It contains fluticasone which is a corticosteroid that helps lower inflammation in your lungs and salmeterol which is a long-acting beta-agonist (LABA) that helps open up your airways in the lungs to make breathing easier.
Does Advair help with cough?
Advair Diskus and Advair HFA are popular brand-name inhalers often prescribed for asthma, chronic obstructive pulmonary disease (COPD), or a persistent cough.
What is fluticasone and salmeterol used for?
Fluticasone and salmeterol is a combination medication that doctors use to treat the symptoms of asthma and chronic obstructive pulmonary disease (COPD). The medication is available as both a powder and an aerosol that people take via an inhaler.
How does fluticasone work?
As a combination medication, fluticasone and salmeterol work together to help manage symptoms of asthma or COPD. The medication is available as either a powder or an aerosol that a person breathes in through an inhaler.
What brand of fluticasone is used for respilick?
Brand names include Advair Diskus and AirDuo RespiClick. The Food and Drug Administration (FDA) recommend that doctors only prescribe fluticasone and salmeterol if other medications are ineffective in controlling a person’s symptoms.
How long does it take for fluticasone to work?
A person may notice an improvement in their symptoms within 30 minutes. People should store the inhaler in a cool, dry area and keep the mouthpiece clean to limit the possibility of infections.
How old do you have to be to take Advair Diskus?
children younger than 4 years of age, for Advair Diskus. people with a severe milk protein allergy. people who are allergic to fluticasone, salmeterol, or any of the ingredients that the medication label lists.
What are the symptoms of allergic reaction to fluticasone?
Possible symptoms of a severe allergic reaction, known as anaphylaxis, include: skin rash or hives. swelling of the lips, tongue, or throat.
When to see a doctor for fluticasone?
When to see a doctor. A person should see their doctor if they experience mild or moderate side effects while taking fluticasone and salmeterol. The doctor may recommend adjusting the dosage or changing to an alternative medication, where possible.
What is fluticasone propionate?
Fluticasone Propionate/Salmeterol DISKUS is for adults and children with asthma who need both an ICS and LABA medicine. COPD: Fluticasone Propionate/Salmeterol DISKUS inhalation powder 250/50 mcg is a prescription medicine used to treat COPD.
How long does it take to discontinue fluticasone propionate?
Fluticasone Propionate/Salmeterol DISKUS should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants, or within 2 weeks of discontinuation of such agents, because the action of salmeterol, a component of Fluticasone Propionate/Salmeterol DISKUS, on the vascular system may be potentiated by these agents.
Is fluticasone soluble in water?
It is practically insoluble in water, freely soluble in dimethyl sulfoxide and dimethylformamide, and slightly soluble in methanol and 95% ethanol. The other active component of Fluticasone Propionate/Salmeterol DISKUS is salmeterol xinafoate, a beta 2 -adrenergic bronchodilator.
Is fluticasone propionate a CYP3A4 inhibitor?
Fluticasone propionate and salmeterol, the individual components of Fluticasone Propionate/Salmeterol DISKUS, are substrates of CYP3A4. The use of strong CYP3A4 inhibitors (e.g., ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, ketoconazole, telithromycin) with Fluticasone Propionate/Salmeterol DISKUS is not recommended because increased systemic corticosteroid and increased cardiovascular adverse effects may occur.
Does fluticasone help with asthma?
Fluticasone propionate, a component of Fluticasone Propionate/Salmeterol DISKUS, will often help control asthma symptoms with less suppression of HPA function than therapeutically equivalent oral doses of prednisone. Since fluticasone propionate is absorbed into the circulation and can be systemically active at higher doses, the beneficial effects of Fluticasone Propionate/Salmeterol DISKUS in minimizing HPA dysfunction may be expected only when recommended dosages are not exceeded and individual patients are titrated to the lowest effective dose. A relationship between plasma levels of fluticasone propionate and inhibitory effects on stimulated cortisol production has been shown after 4 weeks of treatment with fluticasone propionate inhalation aerosol. Since individual sensitivity to effects on cortisol production exists, physicians should consider this information when prescribing Fluticasone Propionate/Salmeterol DISKUS.
Can you take fluticasone with asthma?
Fluticasone Propionate/Salmeterol DISKUS should not be initiated in patients during rapidly deteriorating or potentially life-threatening episodes of asthma or COPD. Fluticasone Propionate/Salmeterol DISKUS has not been studied in subjects with acutely deteriorating asthma or COPD. The initiation of Fluticasone Propionate/Salmeterol DISKUS in this setting is not appropriate.
Is fluticasone a long term asthma medication?
Fluticasone Propionate/Salmeterol DISKUS should be used for patients not adequately controlled on a long-term asthma control medication such as an inhaled corticosteroid (ICS) or whose disease warrants initiation of treatment with both an ICS and long-acting beta 2 -adrenergic agonist (LABA).
How it works
Fluticasone belongs to a class of drugs called inhaled corticosteroids. Salmeterol belongs to a class of drugs called long-acting beta-adrenergic agonists. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
More common side effects
The adult side effects for this drug are slightly different from the side effects for children. For all side effects, if they’re mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.
Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
Antibiotics
Taking antibiotics with fluticasone/salmeterol may increase the amount of fluticasone/salmeterol in your body. This may cause more side effects. Examples of these drugs include:
Antifungal drugs
Taking certain antifungal drugs with fluticasone/salmeterol may increase the amount of fluticasone/salmeterol in your body. This may cause more side effects. Examples of these drugs include:
Depression drugs
Taking certain depression drugs with fluticasone/salmeterol may increase the amount of fluticasone/salmeterol in your body. This may cause more side effects. Examples of these drugs include:
High blood pressure and heart drugs
Taking these drugs with fluticasone/salmeterol can block the action of salmeterol and cause the vessels in your lungs to tighten or constrict. This may make it harder for you to breathe, or put you at a higher risk of lung spasms or asthma attacks.
What is the combination of fluticasone and salmeterol?
The combination of fluticasone and salmeterol (Advair Diskus) is also used to prevent and treat wheezing, shortness of breath, coughing, and chest tightness caused by chronic obstructive pulmonary disease (COPD; a group of lung diseases that includes chronic bronchitis and emphysema). The combination of fluticasone and salmeterol (Advair Diskus) ...
What is the difference between fluticasone and salmeterol?
The combination of fluticasone and salmeterol (Advair HFA, AirDuo Respiclick) is used in children 12 years of age and older. Fluticasone is in a class of medications called steroids. It works by reducing swelling in the airways. Salmeterol is in a class of medications called long-acting beta-agonists (LABAs).
How often should I take salmeterol and fluticasone?
It is usually used twice a day, in the morning and evening, about 12 hours apart. Use fluticasone and salmeterol at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
What is the best medicine for asthma?
The combination of fluticasone and salmeterol (Advair Diskus, Advair HFA, AirDuo Respiclick) is used to treat difficulty breathing, wheezing, shortness of breath, coughing, and chest tightness caused by asthma. The combination of fluticasone and salmeterol (Advair Diskus) is also used to prevent and treat wheezing, shortness of breath, coughing, ...
What are the side effects of salmeterol?
Fluticasone and salmeterol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: 1 runny nose 2 sneezing 3 sore throat 4 throat irritation 5 sinus pain 6 headache 7 nausea 8 vomiting 9 diarrhea 10 stomach pain 11 muscle and bone pain 12 dizziness 13 weakness 14 tiredness 15 sweating 16 tooth pain 17 shaking of a part of your body that you cannot control 18 sleep problems
What does it mean when you cough after taking salmeterol?
hives. rash. swelling of the face, throat, tongue, lips, hands, feet, ankles, or lower legs. choking or difficulty s wallowing . hoarseness. noisy, high-pitched breathing. pounding fast, or irregular heartbeat. fainting.
Can you stop taking fluticasone?
Continue to use fluticasone and salmeterol even if you feel well. Do not stop using fluticasone and salmeterol without talking to your doctor. If you stop using fluticasone and salmeterol inhalation, your symptoms may return.
What is fluticasone and salmeterol used for?
Fluticasone and salmeterol is a combination of two medicines that are used to help control the symptoms of asthma and improve breathing. It is used when a patient's asthma has not been controlled sufficiently on other asthma medicines, or when a patient's condition is so severe that more than one medicine is needed every day.
What is salmeterol used for?
Inhaled salmeterol is a long-acting bronchodilator. Bronchodilators are medicines that are breathed in through the mouth to open up the bron chial tubes (air passages) in the lungs. It relieves cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes.
Brand Names: US
Advair Diskus; Advair HFA; AirDuo Digihaler; AirDuo RespiClick 113/14; AirDuo RespiClick 232/14; AirDuo RespiClick 55/14; Wixela Inhub
Brand Names: Canada
Advair 100 Diskus; Advair 125; Advair 250; Advair 250 Diskus; Advair 500 Diskus; PMS-Fluticasone/Salmeterol DPI; Wixela Inhub
What do I need to tell my doctor BEFORE I take this drug?
If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
What are some things I need to know or do while I take this drug?
Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
What are some other side effects of this drug?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
How is this drug best taken?
Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.
How often should I take fluticasone propionate?
Fluticasone propionate and salmeterol inhalation powder should be administered as 1 inhalation twice daily by the orally inhaled route only. After inhalation, the patient should rinse his/her mouth with water without swallowing to help reduce the risk of oropharyngeal candidiasis.
What is fluticasone propionate used for?
Fluticasone propionate and salmeterol inhalation powder, USP is a prescription medicine used to: Control symptoms of asthma and to prevent symptoms such as wheezing in adults and children aged 4 years and older. Read more. At the 250 mcg/50 mcg strength, treat chronic obstructive pulmonary disease (COPD).
Does fluticasone cause throat pain?
Common side effects of fluticasone propionate and salmeterol inhalation powder, USP in patients with COPD include thrush in the mouth or throat, throat irritation, hoarseness and voice changes, viral respiratory infections, headache and muscle and bone pain. These are not all the possible side effects of fluticasone propionate ...
Can you breathe after taking fluticasone?
Sudden breathing problems immediately after inhaling your medicine. If you have sudden breathing problems immediately after inhaling your medicine, stop using fluticasone propionate and salmeterol inhalation powder, USP and call your healthcare provider right away. Serious allergic reactions.
Does fluticasone propionate cause infection?
Weakened immune system and greater chance of getting infections (immunosuppression). Fluticasone propionate and salmeterol inhalation powder, USP may make you more prone to infection. Chickenpox and measles, for example, can have a more serious or even fatal course in children or adult using corticosteroid.
Can you use fluticasone propionate and salmeterol inhalation powder?
Do not use fluticasone propionate and salmeterol inhalation powder, USP to relieve sudden breathing problems. Always have a rescue inhaler with you to treat sudden symptoms. Do not use fluticasone propionate and salmeterol inhalation powder, USP if you have a severe allergy to milk proteins.
Is fluticasone propionate contraindicated?
The use of fluticasone propionate and salmeterol inhalation powder, USP is contraindicated in the following conditions: Primary treatment of status asthmaticus or other acute episodes of asthma or chronic obstructive pulmonary disease (COPD) where intensive measures are required.
Indications and Usage For Fluticasone and Salmeterol Diskus
- Treatment of Asthma
Fluticasone Propionate/Salmeterol DISKUS is indicated for the twice-daily treatment of asthma in patients aged 4 years and older. Fluticasone Propionate/Salmeterol DISKUS should be used for patients not adequately controlled on a long-term asthma control medication such as an inhale… - Maintenance Treatment of Chronic Obstructive Pulmonary Disease
Fluticasone Propionate/Salmeterol DISKUS inhalation powder 250/50 mcg is indicated for the twice-daily maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema. Fluticasone Propio…
Fluticasone and Salmeterol Diskus Dosage and Administration
- Fluticasone Propionate/Salmeterol DISKUS should be administered as 1 inhalation twice daily by the orally inhaled route only. After inhalation, the patient should rinse his/her mouth with water without swallowing to help reduce the risk of oropharyngeal candidiasis. More frequent administration or a greater number of inhalations (more than 1 inhalation twice daily) of the pres…
Dosage Forms and Strengths
- Inhalation powder: Inhaler containing a foil blister strip of powder formulation for oral inhalation. The strip contains a combination of fluticasone propionate 100, 250, or 500 mcg and salmeterol 50 mcg per blister.
Contraindications
- The use of Fluticasone Propionate/Salmeterol DISKUS is contraindicated in the following conditions: • 1. Primary treatment of status asthmaticus or other acute episodes of asthma or COPD where intensive measures are required [see Warnings and Precautions (5.2)]. • 1. Severe hypersensitivity to milk proteins or demonstrated hypersensitivity to fluticasone propionate, sal…
Warnings and Precautions
- Serious Asthma-Related Events – Hospitalizations, Intubations, Death
Use of LABA as monotherapy (without ICS) for asthma is associated with an increased risk of asthma-related death [see Salmeterol Multicenter Asthma Research Trial (SMART)]. Available data from controlled clinical trials also suggest that use of LABA as monotherapy increases the … - Deterioration of Disease and Acute Episodes
Fluticasone Propionate/Salmeterol DISKUS should not be initiated in patients during rapidly deteriorating or potentially life-threatening episodes of asthma or COPD. Fluticasone Propionate/Salmeterol DISKUS has not been studied in subjects with acutely deteriorating asth…
Adverse Reactions
- Use of LABA may result in the following: • 1. Serious asthma-related events – hospitalizations, intubations, death [see Warnings and Precautions (5.1)] • 1. Cardiovascular and central nervous system effects [see Warnings and Precautions (5.12)] Systemic and local corticosteroid use may result in the following: • 1. Candida albicans infection [see Warnings and Precautions (5.4)] • 1. P…
Drug Interactions
- Fluticasone propionate/salmeterol DISKUS has been used concomitantly with other drugs, including short-acting beta2-agonists, methylxanthines, and intranasal corticosteroids, commonly used in patients with asthma or COPD without adverse drug reactions [see Clinical Pharmacology (12.2)]. No formal drug interaction trials have been performed with fluticasone propionate/salme…
Use in Specific Populations
- Pregnancy
Risk Summary There are insufficient data on the use of fluticasone propionate/salmeterol DISKUS or individual monoproducts, fluticasone propionate and salmeterol xinafoate, in pregnant women. There are clinical considerations with the use of fluticasone propionate/salmeterol DISKUS in pr… - Lactation
Risk Summary There are no available data on the presence of fluticasone propionate or salmeterol in human milk, the effects on the breastfed child, or the effects on milk production. Other corticosteroids have been detected in human milk. However, fluticasone propionate and s…
Overdosage
- No human overdosage data has been reported for fluticasone propionate/salmeterol DISKUS. Fluticasone Propionate/Salmeterol DISKUS contains both fluticasone propionate and salmeterol; therefore, the risks associated with overdosage for the individual components described below apply to Fluticasone Propionate/Salmeterol DISKUS. Treatment of overdosage consists of disco…
Fluticasone and Salmeterol Diskus Description
- Fluticasone Propionate/Salmeterol DISKUS inhalation powder 100/50 mcg, Fluticasone Propionate/Salmeterol DISKUS inhalation powder 250/50 mcg, and Fluticasone Propionate/Salmeterol DISKUS inhalation powder 500/50 mcg are combinations of fluticasone propionate and salmeterol xinafoate. One active component of Fluticasone Propionate/Salmeter…
Medical uses
- The combination of fluticasone and salmeterol (Advair Diskus, Advair HFA, AirDuo Respiclick) is used to treat difficulty breathing, wheezing, shortness of breath, coughing, and chest tightness caused by asthma. The combination of fluticasone and salmeterol (Advair Diskus) is also used to prevent and treat wheezing, shortness of breath, coughing, an...
Use
- The combination of fluticasone and salmeterol comes as a powder and as an inhalation solution to inhale by mouth using a specially designed inhaler. It is usually used twice a day, in the morning and evening, about 12 hours apart. Use fluticasone and salmeterol at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or phar…
Treatment
- Talk to your doctor about how you should take your other oral or inhaled medications for asthma during your treatment with salmeterol and fluticasone inhalation. If you were using a short-acting beta agonist inhaler such as albuterol (Proventil, Ventolin) on a regular basis, your doctor will probably tell you to stop using it regularly but to continue to use it to treat sudden attacks of ast…
Contraindications
- Do not use fluticasone and salmeterol during an attack of asthma or COPD. Your doctor will prescribe a short-acting inhaler to use during attacks.
Results
- Fluticasone and salmeterol inhalation controls the symptoms of certain lung diseases but does not cure these conditions. It may take a week or longer before you feel the full benefit of fluticasone and salmeterol. Continue to use fluticasone and salmeterol even if you feel well. Do not stop using fluticasone and salmeterol without talking to your doctor. If you stop using flutica…
Preparation
- Before you use fluticasone and salmeterol inhalation (Advair Diskus, Advair HFA, or AirDuo Respiclick) for the first time, read the written package instructions that come with it. Look at the diagrams and package instructions carefully and be sure that you recognize all the parts of the inhaler. Ask your doctor, pharmacist, or respiratory therapist to show you how to use the inhaler…
Prevention
- If your child will be using fluticasone and salmeterol inhalation, be sure that he or she knows how to use it. Watch your child each time they use the inhaler to be sure that they are using it correctly. Never exhale into the inhaler, take the inhaler apart, or wash the mouthpiece or any part of the inhaler. Keep the inhaler dry. Do not use the inhaler with a spacer. Keep this medication in the co…
Interactions
- Talk to your doctor about eating grapefruit or drinking grapefruit juice while taking this medication.
Risks
- Fluticasone and salmeterol may cause children to grow more slowly. Your child's doctor will monitor your child's growth carefully. Talk to your child's doctor about the risks of giving this medication to your child. Fluticasone and salmeterol may increase the risk that you will develop glaucoma or cataracts. You will probably need to have regular eye exams during your treatment …