When should fluticasone propionate/salmeterol Diskus be used?
Advair Diskus: After removing from box and foil pouch, write the "Pouch opened" and "Use by" dates (1 month from date of opening) on the label. Every time the lever is pushed back, a dose is ready to be inhaled. Do not close or tilt the Diskus after the lever is pushed back. Do not move the lever more than once.
What is fluticasone and salmeterol inhalation?
Fluticasone propionate and salmeterol inhalation powder, USP is a prescription medicine used to: Control symptoms of asthma and to prevent symptoms such as wheezing in adults and children aged 4 years and older. Read more. At the 250 mcg/50 mcg strength, treat chronic obstructive pulmonary disease (COPD).
What should I know about fluticasone before taking it?
ADVAIR DISKUS & ADVAIR HFA are prescription medications for asthma & ADVAIR DISKUS 250/50 is a prescription medicine for COPD. Learn more about ADVAIR today. Treatment with ADVAIR DISKUS (fluticasone propionate 250mcg and salmeterol 50 mcg inhalation powder) and ADVAIR HFA (fluticasone propionate 45mcg and salmeterol 21 mcg inhalation aerosol)
What are fluticasone and salmeterol used for?
What disorder does Advair Diskus treat?
What is fluticasone Diskus used for?
Is Advair Diskus for asthma or COPD?
How does Advair work in the body?
How does fluticasone propionate work?
When do you take Advair?
- For preventing an asthma attack: Adults and children 12 years of age and older—1 inhalation 2 times per day (morning and evening). The doses should be at least 12 hours apart. ...
- For treatment and prevention of worsening attacks of COPD: Adults—1 inhalation 2 times per day (morning and evening).
What type of drug is salmeterol?
How do you use fluticasone propionate and salmeterol inhaler?
Is fluticasone salmeterol the same as Advair?
Can Advair be used as needed?
What is fluticasone and salmeterol used for?
Fluticasone and salmeterol is a combination medication that doctors use to treat the symptoms of asthma and chronic obstructive pulmonary disease (COPD). The medication is available as both a powder and an aerosol that people take via an inhaler.
What is the difference between fluticasone and salmeterol?
Fluticasone is a corticosteroid that helps reduce inflammation of the airways. Salmeterol is a long acting bronchodilator called a beta-2 agonist that relaxes the muscles around the airways. Together, the two drugs help open up the airways and alleviate breathing difficulties. As a combination medication, fluticasone and salmeterol work together ...
Is fluticasone a bronchodilator?
Fluticasone is a corticosteroid that helps reduce inflammation of the airways. Salmeterol is a long acting bronchodilator called a beta-2 agonist that relaxes the muscles around the airways.
How does fluticasone work?
As a combination medication, fluticasone and salmeterol work together to help manage symptoms of asthma or COPD. The medication is available as either a powder or an aerosol that a person breathes in through an inhaler.
Is fluticasone safe for children?
Fluticasone and salmeterol is not suitable for the following people: children younger than 12 years of age, for AirDuo RespiClick. children younger than 4 years of age, for Advair Diskus. people who are allergic to fluticasone, salmeterol, or any of the ingredients that the medication label lists.
Can fluticasone cause side effects?
Fluticasone and salmeterol can cause side effects in some people. Possible side effects depend on the specific brand of medication. They may also vary according to the condition that the person is treating.
Is fluticasone a combination?
Fluticasone and salmeterol is a combination medication for the management of asthma and COPD symptoms. This medication is available via prescription only. When taking the medication, a person should follow their doctor’s instructions. They should also work closely with their doctor to establish the lowest effective dosage.
Is fluticasone soluble in water?
It is practically insoluble in water, freely soluble in dimethyl sulfoxide and dimethylformamide, and slightly soluble in methanol and 95% ethanol. The other active component of Fluticasone Propionate/Salmeterol DISKUS is salmeterol xinafoate, a beta 2 -adrenergic bronchodilator.
Does fluticasone help with asthma?
Fluticasone propionate, a component of Fluticasone Propionate/Salmeterol DISKUS, will often help control asthma symptoms with less suppression of HPA function than therapeutically equivalent oral doses of prednisone. Since fluticasone propionate is absorbed into the circulation and can be systemically active at higher doses, the beneficial effects of Fluticasone Propionate/Salmeterol DISKUS in minimizing HPA dysfunction may be expected only when recommended dosages are not exceeded and individual patients are titrated to the lowest effective dose. A relationship between plasma levels of fluticasone propionate and inhibitory effects on stimulated cortisol production has been shown after 4 weeks of treatment with fluticasone propionate inhalation aerosol. Since individual sensitivity to effects on cortisol production exists, physicians should consider this information when prescribing Fluticasone Propionate/Salmeterol DISKUS.
Is salmeterol a selective LABA?
Salmeterol is a selective LABA. In vitro studies show salmeterol to be at least 50 times more selective for beta 2 -adrenoceptors than albuterol. Although beta 2 -adrenoceptors are the predominant adrenergic receptors in bronchial smooth muscle and beta 1 -adrenoceptors are the predominant receptors in the heart, there are also beta 2 -adrenoceptors in the human heart comprising 10% to 50% of the total beta-adrenoceptors. The precise function of these receptors has not been established, but their presence raises the possibility that even selective beta 2 -agonists may have cardiac effects.
Is fluticasone a long term asthma medication?
Fluticasone Propionate/Salmeterol DISKUS should be used for patients not adequately controlled on a long-term asthma control medication such as an inhaled corticosteroid (ICS) or whose disease warrants initiation of treatment with both an ICS and long-acting beta 2 -adrenergic agonist (LABA).
What is inhaler powder?
Inhalation powder: Inhaler containing a foil blister strip of powder formulation for oral inhalation. The strip contains a combination of fluticasone propionate 100, 250, or 500 mcg and salmeterol 50 mcg per blister.
Can you take fluticasone with asthma?
Fluticasone Propionate/Salmeterol DISKUS should not be initiated in patients during rapidly deteriorating or potentially life-threatening episodes of asthma or COPD. Fluticasone Propionate/Salmeterol DISKUS has not been studied in subjects with acutely deteriorating asthma or COPD. The initiation of Fluticasone Propionate/Salmeterol DISKUS in this setting is not appropriate.
Does beta-adrenergic stimulation cause seizures?
Excessive beta-adrenergic stimulation has been associated with seizures, angina, hypertension or hypotension, tachycardia with rates up to 200 beats/min, arrhythmias, nervousness, headache, tremor, palpitation, nausea, dizziness, fatigue, malaise, and insomnia [see Overdosage ( 10.2 )]. Therefore, Fluticasone Propionate/Salmeterol DISKUS, like all products containing sympathomimetic amines, should be used with caution in patients with cardiovascular disorders, especially coronary insufficiency, cardiac arrhythmias, and hypertension.
Can fluticasone propionate interact with salmeterol?
Tell your healthcare provider about all of your medical conditions and about all the medicines you take, as fluticasone propionate and salmeterol inhalation powder, USP can interact with other medicines and may cause side effects, in some cases severe.
What is fluticasone propionate used for?
Fluticasone propionate and salmeterol inhalation powder, USP is a prescription medicine used to: Control symptoms of asthma and to prevent symptoms such as wheezing in adults and children aged 4 years and older. Read more. At the 250 mcg/50 mcg strength, treat chronic obstructive pulmonary disease (COPD).
Is fluticasone propionate safe for asthma?
Fluticasone propionate and salmeterol inhalation powder, USP is not for adults and children with asthma who are well controlled with an asthma control medicine , such as a low to medium dose of an inhaled corticosteroid (ICS). Fluticasone propionate and salmeterol inhalation powder, USP is for adults and children with asthma who need both an ICS ...
Is fluticasone propionate contraindicated?
The use of fluticasone propionate and salmeterol inhalation powder, USP is contraindicated in the following conditions: Primary treatment of status asthmaticus or other acute episodes of asthma or chronic obstructive pulmonary disease (COPD) where intensive measures are required.
Indications and Usage For Fluticasone and Salmeterol Diskus
- Treatment of Asthma
Fluticasone Propionate/Salmeterol DISKUS is indicated for the twice-daily treatment of asthma in patients aged 4 years and older. Fluticasone Propionate/Salmeterol DISKUS should be used for patients not adequately controlled on a long-term asthma control medication such as an inhale… - Maintenance Treatment of Chronic Obstructive Pulmonary Disease
Fluticasone Propionate/Salmeterol DISKUS inhalation powder 250/50 mcg is indicated for the twice-daily maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema. Fluticasone Propio…
Fluticasone and Salmeterol Diskus Dosage and Administration
- Fluticasone Propionate/Salmeterol DISKUS should be administered as 1 inhalation twice daily by the orally inhaled route only. After inhalation, the patient should rinse his/her mouth with water without swallowing to help reduce the risk of oropharyngeal candidiasis. More frequent administration or a greater number of inhalations (more than 1 inhalation twice daily) of the pres…
Dosage Forms and Strengths
- Inhalation powder: Inhaler containing a foil blister strip of powder formulation for oral inhalation. The strip contains a combination of fluticasone propionate 100, 250, or 500 mcg and salmeterol 50 mcg per blister.
Contraindications
- The use of Fluticasone Propionate/Salmeterol DISKUS is contraindicated in the following conditions: • 1. Primary treatment of status asthmaticus or other acute episodes of asthma or COPD where intensive measures are required [see Warnings and Precautions (5.2)]. • 1. Severe hypersensitivity to milk proteins or demonstrated hypersensitivity to fluticasone propionate, sal…
Warnings and Precautions
- Serious Asthma-Related Events – Hospitalizations, Intubations, Death
Use of LABA as monotherapy (without ICS) for asthma is associated with an increased risk of asthma-related death [see Salmeterol Multicenter Asthma Research Trial (SMART)]. Available data from controlled clinical trials also suggest that use of LABA as monotherapy increases the … - Deterioration of Disease and Acute Episodes
Fluticasone Propionate/Salmeterol DISKUS should not be initiated in patients during rapidly deteriorating or potentially life-threatening episodes of asthma or COPD. Fluticasone Propionate/Salmeterol DISKUS has not been studied in subjects with acutely deteriorating asth…
Adverse Reactions
- Use of LABA may result in the following: • 1. Serious asthma-related events – hospitalizations, intubations, death [see Warnings and Precautions (5.1)] • 1. Cardiovascular and central nervous system effects [see Warnings and Precautions (5.12)] Systemic and local corticosteroid use may result in the following: • 1. Candida albicans infection [see Warnings and Precautions (5.4)] • 1. P…
Drug Interactions
- Fluticasone propionate/salmeterol DISKUS has been used concomitantly with other drugs, including short-acting beta2-agonists, methylxanthines, and intranasal corticosteroids, commonly used in patients with asthma or COPD without adverse drug reactions [see Clinical Pharmacology (12.2)]. No formal drug interaction trials have been performed with fluticasone propionate/salme…
Use in Specific Populations
- Pregnancy
Risk Summary There are insufficient data on the use of fluticasone propionate/salmeterol DISKUS or individual monoproducts, fluticasone propionate and salmeterol xinafoate, in pregnant women. There are clinical considerations with the use of fluticasone propionate/salmeterol DISKUS in pr… - Lactation
Risk Summary There are no available data on the presence of fluticasone propionate or salmeterol in human milk, the effects on the breastfed child, or the effects on milk production. Other corticosteroids have been detected in human milk. However, fluticasone propionate and s…
Overdosage
- No human overdosage data has been reported for fluticasone propionate/salmeterol DISKUS. Fluticasone Propionate/Salmeterol DISKUS contains both fluticasone propionate and salmeterol; therefore, the risks associated with overdosage for the individual components described below apply to Fluticasone Propionate/Salmeterol DISKUS. Treatment of overdosage consists of disco…
Fluticasone and Salmeterol Diskus Description
- Fluticasone Propionate/Salmeterol DISKUS inhalation powder 100/50 mcg, Fluticasone Propionate/Salmeterol DISKUS inhalation powder 250/50 mcg, and Fluticasone Propionate/Salmeterol DISKUS inhalation powder 500/50 mcg are combinations of fluticasone propionate and salmeterol xinafoate. One active component of Fluticasone Propionate/Salmeter…