Contraindications : Fluconazole is contraindicated in patients who have shown hypersensitivity to fluconazole or to any of its excipients. Co-administration of cisapride or terfenadine contra-indicated.
Full Answer
What are the contraindications for Diflucan (fluconazole)?
Diflucan (fluconazole) is contraindicated in patients who have shown hypersensitivity to fluconazole or to any of its excipients. There is no information regarding cross-hypersensitivity between fluconazole and other azole antifungal agents. Caution should be used in prescribing Diflucan to patients with hypersensitivity to other azoles.
Can fluconazole be taken with an oral anticoagulant?
3. If a patient is taking fluconazole (Diflucan) with an oral anticoagulant, the nurse will monitor for which possible interaction? a. b. d. Some antifungal drugs, including fluconazole and itraconazole, increase the effects of oral anticoagulants, which manifest as increases in PT/INR.
Is it safe to take Diflucan?
A small number of patients (29) ranging in age from 1 day to 6 months have been treated safely with Diflucan. In non-AIDS patients, side effects possibly related to fluconazole treatment were reported in fewer patients aged 65 and older (9%, n =339) than for younger patients (14%, n=2240).
Is fluconazole and quinidine contraindicated with sulfonylurea?
Coadministration of fluconazole and quinidine is contraindicated. (See CONTRAINDICATIONS and PRECAUTIONS .) The effects of fluconazole on the pharmacokinetics of the sulfonylurea oral hypoglycemic agents tolbutamide, glipizide, and glyburide were evaluated in three placebo-controlled studies in normal volunteers.
What are the contraindications for Diflucan?
Who should not take DIFLUCAN?low amount of magnesium in the blood.low amount of potassium in the blood.torsades de pointes, a type of abnormal heart rhythm.prolonged QT interval on EKG.abnormal EKG with QT changes from birth.abnormal liver function tests.pregnancy.chronic kidney disease stage 3A (moderate)More items...
When should I not take fluconazole?
May not be suitable for some people including those with a weakened immune system, diabetes, cancer, or low blood potassium or magnesium levels. The dosage of fluconazole may need to be reduced in people with kidney disease (does not apply to single-dose therapy).
Is fluconazole contraindicated in pregnancy?
Chronic high-dose fluconazole may be teratogenic in humans when used in the first trimester of pregnancy; however, the magnitude of this potential human teratogenic risk is unknown.
What is Diflucan drug used for?
Fluconazole is used to prevent and treat a variety of fungal and yeast infections. It belongs to a class of drugs called azole antifungals. It works by stopping the growth of certain types of fungus.
Is fluconazole safe for heart patients?
Fluconazole may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.
What are the indications of fluconazole?
Hide table of contentsIndicationsGenital candidiasis- Acute vaginal candidiasis - Candidal balanitis- Treatment and prophylaxis of recurrent vaginal candidiasis (4 or more episodes a year).Dermatomycosis- tinea pedis, - tinea corporis, - tinea cruris, - candida infections- tinea versicolor14 more rows
Is fluconazole contraindicated in breastfeeding?
Answer Available data regarding fluconazole use during breastfeeding are reassuring. Fluconazole is also used in the treatment of fungal diseases in infants and has a good safety profile. Therefore, there is no need to interrupt breastfeeding when a mother is treated with fluconazole.
Which antifungal drug is contraindicated during pregnancy?
There are serious risks of fetal malformations associated with the use of griseofulvin, ketoconazole, voriconazole, flucytosine and potassium iodide. These drugs are contraindicated in pregnancy.
Why is Diflucan not safe during pregnancy?
“Specifically, use of high-dose fluconazole during pregnancy has been linked to a pattern of major congenital malformations resembling the Antley-Bixler syndrome, a genetic disorder associated with reduced activity of [the fungal cytochrome P451 enzyme] owing to genetic mutations.
Can Diflucan be used for UTI?
Diflucan also may be effective in treating urinary tract infections, peritonitis, pneumonia and disseminated infections caused by Candida.
Can fluconazole be used for UTI?
Until further studies are performed, a fluconazole 200-mg loading dose followed by 100 mg/d for at least four days appears to be the most appropriate dose for the treatment of symptomatic candidal UTI in patients without systemic fungal infection or severe renal failure.
What are side effects of Diflucan?
SIDE EFFECTS: Nausea, vomiting, diarrhea, stomach upset/pain, headache, dizziness, or hair loss may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Diflucan - Clinical Pharmacology
The pharmacokinetic properties of fluconazole are similar following administration by the intravenous or oral routes. In normal volunteers, the bio...
Indications and Usage For Diflucan
Diflucan (fluconazole) is indicated for the treatment of: 1. Vaginal candidiasis (vaginal yeast infections due to Candida). 2. Oropharyngeal and es...
Diflucan Dosage and Administration
The recommended dosage of Diflucan for vaginal candidiasis is 150 mg as a single oral dose.SINCE ORAL ABSORPTION IS RAPID AND ALMOST COMPLETE, THE...
Principal Display Panel - 100 Mg Tablet Blister Pack
Diflucan®(Fluconazole Tablet)100 mgDistributed byROERIGDIV OF PFIZER INC, NY, NY 10017MADE IN USA (includes foreign content)13041200EXP & LOT AREA
Principal Display Panel - 100 Mg Tablet Blister Pack Carton
UNIT DOSEPfizerNDC 0049-3420-41Diflucan®(Fluconazole Tablets)100 mgFor in-institution use only100 TabletsRx only
Principal Display Panel - 150 Mg Tablet Blister Pack
1 Blister x 1 Tablet*Due to CandidaThe easy ORAL cure for most vaginal yeast* infectionsPfizerDiflucan®(fluconazole tablet)150 mgDirections:Push ta...
Principal Display Panel - 200 Mg Tablet Blister Pack
Diflucan®(Fluconazole Tablet)200 mgDistributed byROERIGDIV OF PFIZER INC, NY, NY 10017MADE IN USA (includes foreign content)13041700EXP & LOT AREA
Principal Display Panel - 200 Mg Tablet Blister Pack Carton
UNIT DOSEPfizerNDC 0049-3430-41Diflucan®(Fluconazole Tablets)200 mgFor in-institution use only100 TabletsRx only
Principal Display Panel - 10 Mg/Ml Bottle Label
PfizerNDC 0049-3440-19Diflucan®(fluconazole) for OralSuspension10 mg/mLORANGE FLAVORED35 mL when reconstitutedRx only
Principal Display Panel - 40 Mg/Ml Bottle Label
PfizerNDC 0049-3450-19Diflucan®(fluconazole) for OralSuspension40 mg/mLORANGE FLAVORED35 mL when reconstitutedRx only
What is the effect of rifampin on fluconazole?
Rifampin: Rifampin enhances the metabolism of fluconazole.
Is fluconazole contraindicated with cisapride?
Fluconazole is contraindicated in patients who have shown hypersensitivity to fluconazole or to any of its excipients. Co-administration of cisapride or terfenadine contra-indicated.
How many patients were treated with diflucan?
Sixteen percent of over 4000 patients treated with Diflucan (fluconazole) in clinical trials of 7 days or more experienced adverse events. Treatment was discontinued in 1.5% of patients due to adverse clinical events and in 1.3% of patients due to laboratory test abnormalities.
How much diflucan is safe for candidiasis?
An open-label, comparative study of the efficacy and safety of Diflucan (2 to 3 mg/kg/day) and oral nystatin (400,000 I.U. 4 times daily) in immunocompromised children with oropharyngeal candidiasis was conducted. Clinical and mycological response rates were higher in the children treated with fluconazole.
How many mg of diflucan are in a blister?
Diflucan Tablets: Pink trapezoidal tablets containing 50, 100, or 200 mg of fluconazole are packaged in bottles or unit dose blisters. The 150 mg fluconazole tablets are pink and oval shaped, packaged in a single dose unit blister.
How much fluconazole is in an open label study?
Azithromycin. An open-label, randomized, three-way crossover study in 18 healthy subjects assessed the effect of a single 800 mg oral dose of fluconazole on the pharmacokinetics of a single 1200 mg oral dose of azithromycin as well as the effects of azithromycin on the pharmacokinetics of fluconazole.
What is fluconazole used for?
Fluconazole is a highly selective inhibitor of fungal cytochrome P450 dependent enzyme lanosterol 14-α-demethylase. This enzyme functions to convert lanosterol to ergosterol. The subsequent loss of normal sterols correlates with the accumulation of 14-α-methyl sterols in fungi and may be responsible for the fungistatic activity of fluconazole. Mammalian cell demethylation is much less sensitive to fluconazole inhibition.
How much water to add to fluconazole suspension?
Prepare a suspension at time of dispensing as follows: tap bottle until all the powder flows freely. To reconstitute, add 24 mL of distilled water or Purified Water (USP) to fluconazole bottle and shake vigorously to suspend powder. Each bottle will deliver 35 mL of suspension. The concentrations of the reconstituted suspensions are as follows:
How much azithromycin is in a crossover study?
Azithromycin. An open-label, randomized, three-way crossover study in 18 healthy subjects assessed the effect of a single 1200 mg oral dose of azithromycin on the pharmacokinetics of a single 800 mg oral dose of fluconazole as well as the effects of fluconazole on the pharmacokinetics of azithromycin.
How to report diflucan side effects?
These are not all the possible side effects of Diflucan. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is fluconazole used for?
Fluconazole is a highly selective inhibitor of fungal cytochrome P450 dependent enzyme lanosterol 14-α-demethylase. This enzyme functions to convert lanosterol to ergosterol. The subsequent loss of normal sterols correlates with the accumulation of 14-α-methyl sterols in fungi and may be responsible for the fungistatic activity of fluconazole. Mammalian cell demethylation is much less sensitive to fluconazole inhibition.
What is diflucan used for?
Diflucan is a prescription medicine used to treat the symptoms of fungal infections. Diflucan may be used alone or with other medications.
How much azithromycin is in a crossover study?
Azithromycin. An open-label, randomized, three-way crossover study in 18 healthy subjects assessed the effect of a single 1200 mg oral dose of azithromycin on the pharmacokinetics of a single 800 mg oral dose of fluconazole as well as the effects of fluconazole on the pharmacokinetics of azithromycin.
Does fluconazole increase nortriptyline?
Fluconazole increases the effect of amitriptyline and nortriptyline. 5-Nortriptyline and/or S-amitriptyline may be measured at initiation of the combination therapy and after 1 week. Dosage of amitriptyline/nortriptyline should be adjusted, if necessary.
Is fluconazole a CYP3A4 inhibitor?
(See CONTRAINDICATIONS.) Fluconazole is a moderate CYP2C9 and CYP3A4 inhibitor. Fluconazole is also a strong inhibitor of CYP2C19. Patients treated with DIFLUCAN, who are also concomitantly treated with drugs with a narrow therapeutic window metabolized through CYP2C9 and CYP3A4, should be monitored for adverse reactions associated with the concomitantly administered drugs. In addition to the observed /documented interactions mentioned below, there is a risk of increased plasma concentration of other compounds metabolized by CYP2C9, CYP2C19, and CYP3A4 coadministered with fluconazole. Therefore, caution should be exercised when using these combinations and the patients should be carefully monitored. The enzyme inhibiting effect of fluconazole persists 4 to 5 days after discontinuation of fluconazole treatment due to the long half-life of fluconazole. Clinically or potentially significant drug interactions between DIFLUCAN and the following agents/classes have been observed and are described in greater detail below:
Does Diflucan help with candidiasis?
DIFLUCAN is also indicated to decrease the incidence of candidiasis in patients undergoing bone marrow transplantation who receive cytotoxic chemotherapy and/or radiation therapy.
What should I avoid while using Diflucan?
Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.
What other drugs will affect Diflucan?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
What is Diflucan?
Diflucan ( fluconazole) is an oral (taken by mouth) antifungal medicine. Diflucan is available as a tablet or as an oral suspension (liquid).
How should I take Diflucan?
Take Diflucan exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.
How long after last fluconazole can you give birth control?
Fluconazole may harm an unborn baby. Use effective birth control to prevent pregnancy while taking this medicine and for at least 1 week after your last dose.
What to tell your doctor before taking diflucan?
Before taking Diflucan, tell your doctor if you have liver disease, kidney disease, a heart rhythm disorder, or a history of Long QT syndrome. Take this medicine for the full prescribed length of time.
Is diflucan safe for seizures?
seizure medicine; or. steroid medicine. To make sure Diflucan is safe for you, tell your doctor if you have ever had: liver disease; heart problems; or. if you are allergic to other antifungal medicine (such as ketoconazole, itraconazole, miconazole, posaconazole, voriconazole, and others).
What are the adverse reactions of amphotericin B?
Once the intravenous infusion of amphotericin B has begun, vital signs must be monitored frequently to assess for adverse reactions such as cardiac dysrhythmias, visual disturbances, paresthesias (numbness or tingling of the hands or feet), respiratory difficulty, pain, fever, chills, and nausea.
What are the contraindications for antifungal drugs?
Liver failure, kidney failure, and porphyria (for griseofulvin) are the most common contraindications for antifungal drugs. The other options are not contraindications. Click again to see term 👆. Tap again to see term 👆. Nice work!
How long does fluconazole last?
1. A patient will be taking fluconazole (Diflucan) 100 mg/day PO for 2 weeks. The patient is unable to swallow tablets, so an oral suspension that contains 10 mg/mL is available.
What is caspofungin used for?
Caspofungin is used for treating severe infection by Aspergillus species (invasive aspergillosis) in patients who are intolerant of or refractory to other drugs. 8. A patient with a severe fungal infection has orders for voriconazole (Vfend).
Why is voriconazole contraindicated?
Voriconazole is contraindicated when coadministered with certain other drugs metabolized by the cytochrome P-450 enzyme 3A4 (e.g., quinidine) because of the risk for inducing serious cardiac dysrhythmias.
Is amphotericin B expensive?
However, the lipid formulations are more costly. 6. The nurse is reviewing instructions for vaginal antifungal drugs with a patient.
Does fluconazole increase bleeding?
Some antifungal drugs, including fluconazole and itraconazole, increase the effects of oral anticoagulants, which manifest as increases in PT/INR. As a result, increased bleeding may occur.
How long after fluconazole can you take voriconazole?
Monitoring for adverse events and toxicity related to voriconazole is recommended; especially, if voriconazole is started within 24 h after the last dose of fluconazole.
How much azithromycin is in a crossover study?
Azithromycin. An open-label, randomized, three-way crossover study in 18 healthy subjects assessed the effect of a single 1200 mg oral dose of azithromycin on the pharmacokinetics of a single 800 mg oral dose of fluconazole as well as the effects of fluconazole on the pharmacokinetics of azithromycin.
Can you take fluconazole with olaparib?
Moderate inhibitors of CYP3A4 such as fluconazole increase olaparib plasma concentrations; concomitant use is not recommended. If the combination cannot be avoided, reduce the dose of olaparib as instructed in the Lynparza (Olaparib) Prescribing Information.
Does fluconazole decrease astemizole?
Concomitant administration of fluconazole with astemizole may decrease the clearance of astemizole.
Is fluconazole a CYP3A4 inhibitor?
Fluconazole is a moderate CYP2C9 and CYP3A4 inhibitor. Fluconazole is also a strong inhibitor of CYP2C19.
Does fluconazole increase halofantrine?
Fluconazole can increase halofantrine plasma concentration due to an inhibitory effect on CYP3A4.
Is Fluconazole a calcium channel blocker?
Certain calcium channel antagonists ( nifedipine, isradipine, amlodipine, verapamil, and felodipine) are metabolized by CYP3A4. Fluconazole has the potential to increase the systemic exposure of the calcium channel antagonists. Frequent monitoring for adverse events is recommended.