- Understanding First-Line Treatment. First-line treatment is usually the standard treatment (the "gold standard") given when someone is diagnosed with a particular disease or condition, such as lung cancer.
- Questions to Ask. When you and your healthcare provider consider a first-line treatment or first-line treatments, think through these questions.
- Alternative and Complementary Treatments. It's important when talking about treatment to clarify what is meant by "alternative treatments." Most people now use the phrase alternative treatments to refer to complementary ...
What is the definition of first line therapy?
First line therapy is the treatment regimen or regimens that are generally accepted by the medical establishment for initial treatment of a given type and stage of cancer. It is also called primary treatment or therapy. The intent of first-line therapy is to cure the cancer if possible. Also called induction therapy, this primary therapy is the ...
What is first line of therapy?
First-line treatment or therapy simply refers to the initial, or first treatment recommended for a disease or illness. This may also be referred to as primary treatment, initial treatment, or induction therapy. With many conditions, including cancer, there are many possible treatments that could be effective.
What is the best first line of treatment for hypertension?
- Principles of drug therapy: Chlorthalidone (12.5-25 mg) is the preferred diuretic because of long half-life and proven reduction of CVD risk. ...
- Initial first-line therapy for stage 1 hypertension includes thiazide diuretics, CCBs, and ACE inhibitors or ARBs. ...
- CKD: BP goal should be <130/80 mm Hg. ...
What is first-line chemotherapy?
Traditional MVAC was initially the standard first-line chemotherapy regime in medically fit patients (Calabrò and Sternberg, 2012; Yagoda, 1983). It was found that patients experienced significant morbidity and toxicity from therapy.
What is first line drug definition?
a drug that is the first choice for treating a particular condition because it is considered a very effective treatment for that condition with the least likelihood of causing side effects. A first-line medication may be a class of drugs (e.g., SSRIs for depression) as well as a single drug.
How do you define therapy lines?
A line of therapy consists of ≥1 complete cycle of a single agent, a regimen consisting of a combination of several drugs, or a planned sequential therapy of various regimens (eg, 3-6 cycles of initial therapy with bortezomib-dexamethasone [VD] followed by stem cell transplantation [SCT], consolidation, and ...
What is a first line indication?
As the evidence and consensus for use of the drug increases and strengthens, its class of indication is improved. Preferred drugs (and other treatments) are also referred to a "first line" or "primary" while others are called "second line", "third line" etc.
What are first and second line treatments?
Second-line treatment is treatment for a disease or condition after the initial treatment (first-line treatment) has failed, stopped working, or has side effects that aren't tolerated. It's important to understand "lines of treatment" and how they differ from first line treatment and can play a role in clinical trials.
What is the first-line treatment for Covid 19?
What treatments are available for COVID-19? The FDA has approved the antiviral drug Veklury (remdesivir) for adults and certain pediatric patients with COVID-19. This is an intravenous therapy (IV). The FDA has also approved the immune modulator Olumiant (baricitinib) for certain hospitalized adults with COVID-19.
What does third line treatment mean?
Treatment that is given when both initial treatment (first-line therapy) and subsequent treatment (second-line therapy) don't work, or stop working.
What is a first line antibiotic?
Amoxicillin and penicillin V remain first-line therapy due to their reliable antibiotic activity against GAS. For penicillin-allergic patients, cephalexin, cefadroxil, clindamycin, or macrolides are recommended. GAS antibiotic resistance to azithromycin and clindamycin are increasingly common.
What is first line treatment for hypertension?
There are three main classes of medication that are usually in the first line of treatment for hypertension: 1. Calcium Channel Blockers (CCB) 2. Angiotensin Converting Enzyme inhibitors (ACE inhibitors or ACE-I) and Angiotensin Receptor Blockers (ARBs) 3. Diuretics.
What is the first line treatment for chemotherapy?
The standard first-line chemotherapy for all patients is bleomycin, etoposide, and cisplatin (BEP) using a 5-day schedule. Modifications in BEP, such as substitution of cisplatin with carboplatin to reduce toxicity or improve convenience, should be avoided because they may reduce efficacy.
What are second-line therapies?
Treatment that is given when initial treatment (first-line therapy) doesn't work, or stops working.
What are second-line drugs?
Any therapeutic agent that is not the drug of choice, or the 1st normally used to treat a particular condition; in rheumatoid arthritis, 2nd-line agents are used when standard 'first-line' therapy–ie, anti-inflammatory agents and corticosteroids fail.
What is second-line antibiotics?
Antibiotics were classified as “first-line” (amoxicillin, TMP-SMX, or erythromycin) or “second-line” (clarithromycin, azithromycin, amoxicillin-clavulanate, cephalosporin, or fluoroquinolone).
What is the first line of treatment?
First line therapy is the treatment regimen or regimens that are generally accepted by the medical establishment for initial treatment of a given type and stage of cancer. It is also called primary treatment or therapy. The intent of first-line therapy is to cure the cancer if possible. Also called induction therapy, this primary therapy is the first assault of chemotherapy drugs on the malignancy.
What is the intent of first line therapy?
The intent of first-line therapy is to cure the cancer if possible. Also called induction therapy, this primary therapy is the first assault of chemotherapy drugs on the malignancy.
What is second line therapy?
Second-line therapies are those tried when the first ones do not work adequately. The management of a cancer case requires regular evaluation of treatment and adjustment as needed. A break with the primary treatment and an adoption of a new regimen signals “second-line treatment.”.
Is salvage therapy considered third line therapy?
The terms “third-line therapy ” and even “fourth-line therapy” are occasionally used for subsequent treatment, but salvage therapy is also used. Written guidelines rarely specify anything beyond second-line therapy. The same treatments can be used for subsequent treatment.
Can a first line therapy be approved for second line therapy?
Sometimes first-line therapies show progress for a period of time followed by a stalling or continued growth of the cancer. Often the FDA will specifically approve a new drug for second-line therapy. This labeling is common for new drugs that treat cancers which already have accepted treatments.
Is there a law on first line therapy?
There is no law, or even a community of practice rule, that doctors must use the accepted first-line therapy for a patient, ...
Is there a law that states that doctors must use first line therapy?
There is no law, or even a community of practice rule, that doctors must use the accepted first-line therapy for a patient, although when they do they “cover their backsides” to some extent and reduce their exposure to malpractice suits. Second-line therapies are those tried when the first ones do not work adequately.
Why is DTG used in HIV treatment?
NOTE OF CAUTION The organisation says it is updating its HIV therapy guidelines to strengthen its recommendation for dolutegravir (DTG) drug as the first-line treatment because of its efficacy, tolerability and a high genetic barrier to resistance. WHO recommends once feared drug to treat HIV.
Is Palbociclib a first line treatment?
Pfizer's NDA for palbociclib, in combination with letrozole, has been accepted for filing and granted Priority Review by the FDA as a first-line treatment for postmenopausal women with estrogen receptor positive (ER+), human epidermal growth factor receptor 2 negative (HER2-) advanced breast cancer who have not received previous treatment.
What makes a drug first line?
What makes a drug first-line? These are the medicines doctors first resort to for a given disease (the doctors first choice try). They are the most commonly prescribed medicines for a particular disease. These medicines are well accepted by the medical community. For asthma, they include systemic corticosteroids like Flovent, Asmanex, and Qvar.
Is corticosteroids a first line treatment for COPD?
So, it remains a first-line treatment for COPD. Likewise, because it may help some asthmatics, it remains a second-line option here. Researchers learn more. Back in the 1970s, doctors were leary that inhaled corticosteroids (ICS) may cause the same side effects as systemic corticosteroids.
Is Atrovent a first line asthma medicine?
Atrovent was once-upon-a-time considered a first-line asthma medicine. It fit all the qualifications of one. But, subsequent studies did not show it benefited most asthmatics. Studies do show, however, that it does help most COPDers. So, it remains a first-line treatment for COPD.
Understanding First-Line Treatment
Questions to Ask
- When you and your healthcare provider consider a first-line treatment or first-line treatments, think through these questions. 1. Clarify the type and stage and molecular profile of your tumor. Is there any further testing that should be done? (If you've been diagnosed with advanced cancer, ask about the molecular profile of your tumor, and if this hasn't been done, ask why not). 2. What is y…
Alternative and Complementary Treatments
- It's important when talking about treatment to clarify what is meant by "alternative treatments." Most people now use the phrase alternative treatments to refer to complementary treatments that are offered by some cancer centers. In this setting, therapies such as acupuncture, meditation, massage, and yoga are used in an integrative fashion—that is, they are used along with tradition…