Treatment FAQ

estrogen for the treatment of women who already have osteoporosis

by Mrs. Dorothea Schimmel Published 3 years ago Updated 2 years ago
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The U.S. Food and Drug Administration has approved the use of estrogen for prevention, but not treatment, of postmenopausal osteoporosis

Osteoporosis

A condition where bone strength weakens and is susceptible to fracture.

. No large treatment trials have examined the effect of estrogen in reducing fractures in women with existing osteoporosis.

Raloxifene is approved for preventing and treating osteoporosis in postmenopausal women. It is from a class of drugs called selective estrogen receptor modulators (SERMs), which are estrogen-like medications. SERMs act like estrogen in some parts of the body but block the effects of estrogen in other parts.Jan 23, 2022

Full Answer

Does estrogen help with osteoporosis?

The Women's Health Initiative (WHI) randomized controlled trial first proved hormonal therapy (HT) reduces the incidence of all osteoporosis-related fractures in postmenopausal women. However, the study concluded that the adverse effects outweighed the potential benefits on bone, leading to a significant decrease in HT use for menopausal ...

How does estrogen affect osteoporosis?

Apr 09, 2018 · It would stand to reason that hormone replacement therapy (HRT) using estrogen would be a viable treatment for osteoporosis. After all, our bodies did a great job of making bone when our estrogen levels were “normal” – so replacing the estrogen should reduce bone resorption, correct?

Does estrogen increase bone density?

Abstract. Osteoporosis is a worldwide problem that results in fractures that lead to disability and high costs to society. Estrogen therapy is frequently utilized for postmenopausal symptoms, but also has proven protective effects on the skeleton. The main action of estrogen at the cellular level is to inhibit the osteoclast by increasing ...

What is the best treatment for osteoporosis?

Mar 09, 2018 · When the American College of Physicians (ACP) recently updated its guidelines for treating osteoporosis (Qaseem et al, 2017), tucked in with the usual recommendations for drug therapy was something major: The ACP reversed its position on estrogen therapy for osteoporosis. In 2008, ACP guidelines supported estrogen therapy based on “high-quality …

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Can taking estrogen help with osteoporosis?

Estrogen replacement therapy used to be the only FDA-approved treatment to prevent osteoporosis. There are now many other drugs and medications for osteoporosis, but estrogen remains a fairly common treatment to conserve bone mass and prevent osteoporosis-related fractures in post-menopausal women.

Does estrogen affect osteoporosis?

Estrogen (E) deficiency causes both the early and late forms of osteoporosis in postmenopausal women and contributes to the development of osteoporosis in elderly men (1).

Can you take hormone therapy and osteoporosis?

It can help to prevent osteoporosis in the years around the menopause, especially if you have an early menopause. It can also be a good choice if you need treatment for both osteoporosis and menopausal symptoms. HRT is safe and effective when prescribed in the right way, for the right women.

What are the signs of low estrogen?

Signs of low estrogen include:
  • Dry skin.
  • Tender breasts.
  • Weak or brittle bones.
  • Trouble concentrating.
  • Moodiness and irritability.
  • Vaginal dryness or atrophy.
  • Hot flashes and night sweats.
  • Irregular periods or no periods (amenorrhea).
Feb 8, 2022

Does low estrogen cause osteoporosis?

When you reach menopause, your estrogen levels drop. In some cases, this decrease in estrogen can lead to bone loss, according to the National Osteoporosis Foundation (NOF).Mar 18, 2016

What is the best HRT for osteoporosis?

Tibolone, a selective tissue estrogenic activity regulator (STEAR), is effective in the treatment of vasomotor symptoms, vaginal atrophy and prevention/treatment of osteoporosis with a clinical efficacy similar to that of conventional HRT.

Should I take HRT if I have osteoporosis?

For women affected by osteoporosis aged under 60, HRT has a role to play in the management of osteoporosis. Women who experience an early menopause, either natural or surgical, should be recommended HRT and advised to continue until at least the normal age of the menopause (51).Jan 12, 2016

Does estrogen increase bone density?

Low-dose estrogen significantly increased bone density at all BMD sites compared with placebo (Table 3 and Figure 2).Aug 27, 2003

Is estrogen good for osteoporosis?

If you have a high risk for osteoporosis and are approaching or have already reached menopause, estrogen replacement therapy may be a good osteoporosis treatment or preventative measure. Estrogen is a sex hormone that is essential to female bone health because it promotes the activity of osteoblasts, which are cells that produce bone.

Is estrogen replacement therapy good for osteoporosis?

If you have a high risk for osteoporosis and are approaching or have already reached menopause, estrogen replacement therapy may be a good osteoporosis treatment or preventative measure.

Is estrogen replacement therapy safe?

Potential Risks. Though estrogen replacement therapy was once the only approved osteoporosis medication, it is not as widely used today. Part of the reason for this is because the therapy has been connected to increased risks of uterine cancer, breast cancer, stroke, heart attacks, blood clots, and even mental decline.

Can you take estrogen if you have a hysterectomy?

However, if you have had a hysterectomy, involving the removal of your uterus, or were born without a uterus, you can safely take estrogen alone because you have no risk for developing uterine cancer. The ideal time to begin estrogen replacement therapy is during early menopause.

Can lack of estrogen cause osteoporosis?

Although a lack of estrogen may not be the entire cause of your osteoporosis, it could certainly play a significant role. There are a lot of other risk factors to consider as well.

How many women have osteoporosis?

When you’re 60, you have a 1 in 10 chance of having osteoporosis, but by the time you’re 90, that about two-thirds of women have osteoporosis. There is a slew of risk factors for ...

How to prescribe HRT?

Yes – in theory. Physicians prescribe HRT to the following women: 1 Postmenopausal who had an early menopause. 2 Women with a low bone mass, verified by a bone density test, plus menopausal symptoms. 3 Several other risk factors for osteoporosis, such as a petite frame, a family history of osteoporosis, or a medical problem that is complicated by osteoporosis.

What are the risk factors for osteoporosis?

For example, being prescribed certain medications seem to increase the likelihood of osteoporosis – corticosteroids and proton pump inhibitors. Having a genetic predisposition, a low body weight, weight loss, smoking, and being physically inactive are all other risk factors.

What does it mean when you have osteoporosis?

If you’re reading this, you likely know what osteoporosis is, but if we break down the word literally, it means “porous bone.”. When you develop osteoporosis, you are at a significantly increased risk for bone fractures due to a loss of bone strength and mass.

Can osteoporosis cause bone loss?

When you develop osteoporosis, you are at a significantly increased risk for bone fractures due to a loss of bone strength and mass. Unfortunately for many women, osteoporosis is sometimes not diagnosed until a major fracture occurs, such as in the back or the hips.

What happens to bone mass after age 35?

After age 35, bone breakdown overtakes bone buildup, which causes a gradual loss of bone mass. Once this loss of bone reaches a certain point, a person has osteoporosis.”. There seems to be a distinct relationship between menopause and osteoporosis. Once a woman has reached menopause, her estrogen levels decrease.

Is estrogen therapy good for osteoporosis?

Estrogen therapy isn’t an option for osteoporosis anymore. When the American College of Physicians (ACP) recently updated its guidelines for treating osteoporosis (Qaseem et al, 2017), tucked in with the usual recommendations for drug therapy was something major: The ACP reversed its position on estrogen therapy for osteoporosis.

What is the ACP guideline?

The ACP’s guideline assumes that drug therapy is the best approach. The Europeans look at it differently — and so do I. My Better Bones, Better Body approach has stayed ...

Does estrogen help with osteoporosis?

The role of estrogen treatments for osteoporosis has changed. We know the female hormone estrogen plays a role in building new bone and maintaining bone density. After menopause, women’s bodies experience a sharp drop in estrogen levels. This impacts the body’s ability to rebuild bone efficiently. Eventually, this may result in a loss ...

Does hormone replacement therapy help with osteoporosis?

In the past, this was the primary form of treatment for osteoporosis. 5 Things You Didn't Know About Osteoporosis.

Can osteoporosis cause fractures?

Osteoporosis is a common condition in which your bones become porous and fragile, increasing the risk of fractures. It can affect anyone, but it’s seen most frequently in older post-menopausal women. For many years, treatments with the hormone estrogen were used to prevent further bone loss in women with osteoporosis.

What is the most common treatment for osteoporosis?

This has led to the development of many additional non-hormonal treatments for osteoporosis, including: Bisphosphonates: This is the most common type of medication used to treat osteoporosis. They slow down the rate at which your bones are broken down, giving bone-forming cells more time to rebuild.

What to do if you have osteoporosis?

If you have osteoporosis or are at high risk of developing it, talk to your doctor about what treatments are appropriate for you. With the right treatment, you can protect your bones, allowing you to live an active and healthy life.

What happens to the body after menopause?

After menopause, women’s bodies experience a sharp drop in estrogen levels. This impacts the body’s ability to rebuild bone efficiently. Eventually, this may result in a loss of bone mass and lead to the development of osteoporosis. Knowing the relationship between estrogen and osteoporosis, it makes sense that treating post-menopausal women ...

Who is Erin Azuse?

Erin Azuse, RN, has been a registered nurse for 18 years, working in neonatal intensive care and pediatrics. She specializes in creating educational materials for patients, consumers, and other healthcare providers, as well as content marketing for private physicians’ practices, medical device companies, and nursing schools.

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