How effective is S-adenosylmethionine for pain relief?
What is this medicine? S-ADENOSYL-L-METHIONINE, SAM-E (S-a DEN o sil L-me THYE o neen) is a dietary supplement. It is often promoted to help support healthy moods, joints, and liver function. The FDA has not approved this supplement for any medical use. This medicine may be used for other purposes; ask your health care provider or pharmacist if ...
What is a typical dosage of same for osteoarthritis?
S-Adenosyl-L-methionine (also called S-adenosyl methionine, S-adenosylmethionine, SAMe, or SAM-e in the United States or ademetionine in Europe, and also often abbreviated as SAM and AdoMet) is a chemical that is found naturally in the body. SAMe is sold in the United States as a dietary supplement.
What is same (adenosylmethionine)?
SAMe can also increase the activity of antidepressants. If you take anticoagulants, you should take SAMe under your doctor’s supervision because it might increase the risk of bleeding. We don’t yet know what the best dose of SAMe is, but most studies have used daily doses of 400–1,600 mg.
What is Samsam-E for fibromyalgia?
Apr 08, 2021 · A typical dosage of SAMe for osteoarthritis 600 mg to 1200 mg each day, divided into three doses. Other drugs used to treat arthritis include methotrexate, which has shown benefits in reducing inflammation and disease progression in studies of the drug for hand and knee osteoarthritis.
Is Sam E a compound?
SAM-e is a compound that's made naturally in the body and plays an important role in normal bodily function. A synthesized form of SAM-e is considered a supplement in the U.S., but SAM-e has been sold as a prescription drug in parts of Europe for decades. Its scientific name is S-adenosylmethionine. SAM-e is also known as ademetionine and SAMe.
Is Sam E a supplement?
A synthesized form of SAM-e is considered a supplement in the U.S., but SAM-e has been sold as a prescription drug in parts of Europe for decades. Its scientific name is S-adenosylmethionine. SAM-e is also known as ademetionine and SAMe.
Why do people take Sam E?
Why do people take SAM-e? SAM-e has some evidence as a treatment for osteoarthritis pain. Some studies have found that oral SAM-e is as effective as NSAID painkillers, such as ibuprofen and Celebrex. SAM-e takes longer to act than drugs do, but it also has fewer side effects than NSAIDs.
Is Sam E as effective as Celebrex?
SAM-e has some evidence as a treatment for osteoarthritis pain. Some studies have found that oral SAM-e is as effective as NSAID painkillers, such as ibuprofen and Celebrex. SAM-e takes longer to act than drugs do, but it also has fewer side effects than NSAIDs.
Is Sam E good for osteoarthritis?
SAM-e has some evidence as a treatment for osteoarthritis pain. Some studies have found that oral SAM-e is as effective as NSAID painkillers, such as ibuprofen and Celebrex. SAM-e takes longer to act than drugs do, but it also has fewer side effects than NSAIDs. SAM-e has also been used to treat depression for many years.
Does Sam E work?
SAM-e has also been used to treat depression for many years. Some studies have found that SAM-e might work as well as tricyclic antidepressants in relieving symptoms.
Does Sam E help with fibromyalgia?
However, many of these studies were flawed or too small to be conclusive. Other uses of SAM-e have not been studied as thoroughly. There's some evidence that SAM-e might help ease the pain of fibromyalgia and spinal cord damage caused by HIV. SAM-e may also help control cholestasis -- a buildup of bile in the liver -- particularly in pregnant women ...
Overview
S-adenosyl-L-methionine (SAMe) is a compound found naturally in the body. SAMe helps produce and regulate hormones and maintain cell membranes.
Our take
SAMe appears to be safe and might be effective in treating depression and osteoarthritis. However, SAMe might interact with antidepressants. Don't use SAMe and prescription antidepressants together.
Interactions
Antidepressants and other drugs and supplements that increase levels of serotonin. Don't take SAMe with antidepressants. The combination could cause effects similar to a condition caused by high levels of the chemical serotonin to accumulate in your body (serotonin syndrome).
What is the chemical name for SAM?
S-Adenosyl-L-methionine (also called S-adenosyl methionine, S-adenosylmethionine, SAMe, or SAM-e in the United States or ademetionine in Europe, and also often abbreviated as SAM and AdoMet) is a chemical that is found naturally in the body. SAMe is sold in the United States as a dietary supplement.
Is Same good for osteoarthritis?
The idea that SAMe might be helpful for osteoarthritis came from studies of SAMe for depression. Some of the participants in the depression studies who also had osteoarthritis said their joint symptoms improved when they took SAMe.
Does Same help with osteoarthritis?
Evidence suggests that SAMe is effective in reducing functional limitations and, to a lesser extent, pain in osteoarthritis . Evidence for its effectiveness for fibromyalgia suggests that SAMe might be useful for reducing body tenderness ...
Does Same help with pain?
Laboratory studies suggested that SAMe has some painkilling activity and stimulates the production of collagen and proteoglycans, which are major building blocks of cartilage.
What is the scientific name for a compound made of methionine?
Scientific name: S-adenosylmethionine. SAMe is a chemical compound made from methionine, an amino acid also found in protein-rich foods, and adenosine triphosphate (ATP), a nucleic acid and the product of some chemical reactions in your body. SAMe was discovered in 1952 and was first studied as a possible treatment for depression.
What is the best medication for arthritis?
Other drugs used to treat arthritis include methotrexate, which has shown benefits in reducing inflammation and disease progression in studies of the drug for hand and knee osteoarthritis. Methotrexate is considered a first-line therapy for rheumatoid arthritis (RA).
Is Same a good supplement for osteoarthritis?
SAMe: The Arthritis Supplement You’ve Never Heard Of. SAMe may be one of the most effective arthritis supplements for osteoarthritis pain that you’ve never heard of. While many studies show it works as well as common pain medications, with fewer side effects, there are also studies that show the opposite. There is still some controversy about SAMe.
What is the most common form of arthritis?
Osteoarthritis is the most common form of arthritis, affecting more than 32 million adults in the United States. It occurs when the smooth cartilage that protects the bones in a person’s joint gradually wears down, causing pain, swelling and stiffness in the joints, and it often gets worse with time.
Does arthritis supplement help with pain?
The arthritis supplement works as a pain reliever and appears to have anti- inflammatory properties, according to many studies, while animal studies indicate it may stimulate cartilage growth and impact serotonin, decreasing the perception of pain. A 2002 meta-analysis (a review of a number of independent studies of the same subject, ...
What NSAIDs are used for arthritis?
Common NSAIDs include aspirin, Advil or Motrin (ibuprofen) and Aleve (naproxen). Celebrex (celecoxib), which is often used to treat arthritis, belongs to a class of NSAIDs known as COX-2 inhibitors and aims to avoid stomach upset. A 2009 study in the journal Clinical Therapeutics compared 1200 mg per day of SAMe to 1000 mg per day ...
Does Same help with osteoarthritis?
It’s most likely to affect a person’s hands, back, neck, hips and knees. “SAMe is one of the handful of natural supplements that does have fair evidence that it helps for the pain of osteoarthritis ,” says Richard Saint Cyr, MD, a primary care physician at Swedish Bainbridge Island Primary Care in Bainbridge Island, Wash.
Is glucosamine the same as turmeric?
It doesn’t have the same name recognition as glucosamine or turmeric, but the Arthritis Foundation’s website cites it as one of the supplements that scientific studies have found to be effective in treating osteoarthritis. Two studies cited by the organization showed it to be as effective as NSAID (nonsteroidal anti-inflammatory drug) painkillers.
Effect of SAM-E on Osteoarthritis
A substantial amount of evidence suggests that SAMe can be an effective treatment for osteoarthritis, the "wear and tear" type of arthritis that many people develop as they get older. 1
Research Evidence on SAM-E
A substantial body of scientific evidence indicates that S-adenosylmethionine (SAMe) can relieve symptoms of arthritis. 50 Numerous double-blind studies involving more than a thousand participants in total suggest that it is approximately as effective for this purpose as standard anti-inflammatory drugs.
How to Use SAM-E
The body makes all the SAMe it needs, so there is no dietary requirement. However, deficiencies in methionine, folate, or vitamin B12 can reduce SAMe levels. SAMe is not found in appreciable quantities in foods, so it must be taken as a supplement.
Side Effects and Warnings
There have been no reported deaths from overdose of SAM-e. Side effects can include headache, nausea, anxiety, insomnia, dry mouth, reduced appetite, sweating, and dizziness.
How to decide if you should take Sam E?
The best way to decide whether you should try SAM-e supplements is to do your research and talk to your doctor about it. Be sure to weigh the risks versus the potential benefits. It's also a good idea to ask your pharmacist about SAM-e or any other supplement you plan to add to your regimen, as well.
What is Sam E?
SAM-e is one of the more popular supplements for fibromyalgia (FMS) and chronic fatigue syndrome (CFS or ME/CFS ). Its full name is s-adenosyl methionine and it's a substance that's made naturally in your body. Its job is to regulate key functions in your cells.
Is Sam E good for FMS?
What the Research Says. Some studies suggest that SAM-e is effective at relieving some F MS symptoms, including pain, morning stiffness and tender-point count, as well as mood disorders and depression symptoms.
Does Sam E help with FMS?
Some studies suggest that SAM-e is effective at relieving some FMS symptoms, including pain, morning stiffness and tender-point count, as well as mood disorders and depression symptoms. It's not as well researched in connection with ME/CFS, but many experts say the research we do have supports its use.
Is Sam E safe for HIV?
SAM-e is also not recommended for anyone with HIV/AIDS. Because of an association with mania and hypomania, those with bipolar disorder, anxiety disorders, or other psychiatric conditions should be under the close supervision of a healthcare provider when taking SAM-e.
Can you take Sam E while pregnant?
Because of an association with mania and hypomania, those with bipolar disorder, anxiety disorders, or other psychiatric conditions should be under the close supervision of a healthcare provider when taking SAM-e. We don't have safety data on SAM-e use during pregnancy or breastfeeding.
Does Sam E help with osteoarthritis?
SAM-e may also reduce inflammation from osteoarthritis. SAM-e is well documented to benefit humans with nervous system disorders, such as fibromyalgia, and the research is forthcoming on SAM-e’s benefits for dogs with nervous system disorders, like as degenerative myelopathy.
Does Sam E help with liver disease?
When this happens, it makes SAM-e supplementation beneficial to dogs with liver disease by supporting the repair, regeneration and overall health of liver cells. SAM-e dog supplements also help promote healthy flow of bile and production of phospholipids, which are necessary for healthy cell membranes.
What is the purpose of Sam E for dogs?
SAM-e dog supplements also help promote healthy flow of bile and production of phospholipids, which are necessary for healthy cell membranes.
Does Sam E help dogs?
SAM-e Benefits Dogs With Dementia and Joint Pain. In human medicine, SAM-e is prescribed for a wide range of conditions, and we now know that SAM-e can also be administered as adjunct therapy for many of the same purposes in dogs. In humans, SAM-e has been used to augment the effect of antidepressant medications in people who suffer from depression.
Can Sam E be used in dogs?
In human medicine, SAM-e is prescribed for a wide range of conditions, and we now know that SAM-e can also be administered as adjunct therapy for many of the same purposes in dogs. In humans, SAM- e has been used to augment the effect of antidepressant medications in people who suffer from depression. It is theorized to work in humans by increasing ...
Can you give Sam E to dogs?
SAM-e is best absorbed on an empty stomach; however, you can hide it in a small treat if you cannot get your dog to swallow it. Make sure that your dog drinks some water after giving SAM-e to ensure that the supplement is completely swallowed.
What is a Sam E dog?
SAM-e is created by the body from an essential amino acid called methionine. SAM-e for dogs is a dietary supplement that mimics the SAM-e that is naturally made by the body. Through chemical processes in the body, SAM-e is converted into glutathione, which is known to have detoxifying ...