
Common tests & procedures
Initial Treatment of Prostate Cancer, by Stage. The stage of your cancer is one of the most important factors in choosing the best way to treat it. Prostate cancer is staged based on the extent of the cancer (using T, N, and M categories) and the PSA level and Gleason score at the time of diagnosis.
How is the initial treatment of prostate cancer determined?
Prostate Cancer: To Treat or Not to Treat? For men with non-aggressive prostate cancer, active surveillance is a viable option. Clark Howard was in Shanghai on a business trip in 2009 when his wife called him, tearful and anguished. A biopsy showed that Howard, then 53, had prostate cancer.
Should prostate cancer be treated?
To give the cancer a grade, the pathologist checks the prostate tissue samples to see how much the tumor tissue is like the normal prostate tissue and to find the two main cell patterns. The primary pattern describes the most common tissue pattern, and the secondary pattern describes the next most common pattern.
How do pathologists grade prostate cancer?
In active surveillance, regular follow-up blood tests, rectal exams and prostate biopsies may be performed to monitor progression of your cancer. If tests show your cancer is progressing, you may opt for a prostate cancer treatment such as surgery or radiation.
What are the tests for prostate cancer?

What is the course of treatment for prostate cancer?
Active surveillance, surgery, and radiation therapy are the standard therapy choices for men with early-stage prostate cancer (see Types of Treatment, starting on page 8). Each has benefits (how treatments can help) and risks (problems treatment may cause). There is seldom just one right treatment choice.
What happens when you are diagnosed with prostate cancer?
Most men with early prostate cancer don't have changes that they notice. Signs of prostate cancer most often show up later, as the cancer grows. Some signs of prostate cancer are trouble peeing, blood in the pee (urine), trouble getting an erection, and pain in the back, hips, ribs, or other bones.
What is the prognosis for someone who is diagnosed with prostate cancer?
10-year relative survival rate of 98 percent: Ten years after diagnosis, the average prostate cancer patient is just 2 percent less likely to survive than a man without prostate cancer.
How many treatments does it take for prostate cancer?
Choosing a Treatment Option Treatment Options for Localized or Locally Advanced Prostate Cancer A man diagnosed with localized or locally advanced prostate cancer has 3 major treatment options: Active Surveillance, surgery, and radiation therapy.
What is the first step after a prostate cancer diagnosis?
At this point, you're going to begin assembling your team of healthcare providers to see you through your treatment. As a first step, you should see an oncologist, along with a radiation oncologist and a urologist. If your cancer is more advanced or more aggressive, you'll probably also be seen by a medical oncologist.
How fast does prostate cancer progress?
In many cases, prostate cancer is relatively slow-growing, which means that it can take years to become large enough to be detectable, and even longer to metastasize outside the prostate. However, some cases are more aggressive and need more urgent treatment.
What is the average age a man gets prostate cancer?
Prostate cancer is more likely to develop in older men and in non-Hispanic Black men. About 6 cases in 10 are diagnosed in men who are 65 or older, and it is rare in men under 40. The average age of men at diagnosis is about 66.
What are the signs that prostate cancer has spread?
Prostate cancer can spread to the lymph nodes in the groin area, or to other parts of the body. The most common symptoms are swelling and pain around the area where the cancer has spread. Cancer cells can stop lymph fluid from draining away. This might lead to swelling in the legs due to fluid build up in that area.
What are the 5 warning signs of prostate cancer?
5 Warning signs are bone pain, compression of the spine, Painful urination, erectile dysfunction, and blood in the urine.
How treatable is prostate cancer if caught early?
The short answer is yes, prostate cancer can be cured, when detected and treated early. The vast majority of prostate cancer cases (more than 90 percent) are discovered in the early stages, making the tumors more likely to respond to treatment.
How soon after prostate cancer diagnosis should surgery be done?
March 9, 2006 -- Men with low-risk prostate cancer can safely wait up to six months to get treated without jeopardizing their chances of cancer progression, a study supported by the National Institutes of Health shows.
When do you start chemo for prostate cancer?
There is no set time when you should start chemotherapy and it is different for every man. It's usually fine to start chemotherapy any time up to three months after starting hormone therapy. If you've already had hormone therapy, chemotherapy is usually given as a course of up to 10 sessions.
Which Treatments Are Used For Prostate Cancer?
Depending on each case, treatment options for men with prostate cancer might include: 1. Watchful waiting or active surveillance 2. Surgery 3. Radi...
Which Doctors Treat Prostate Cancer?
The main types of doctors who treat prostate cancer include: 1. Urologists: surgeons who treat diseases of the urinary system and male reproductive...
Making Treatment Decisions
It’s important to discuss all of your treatment options, including their goals and possible side effects, with your doctors to help make the decisi...
Help Getting Through Treatment
Your cancer care team will be your first source of information and support, but there are other resources for help when you need it. Hospital- or c...
What are the treatment options for prostate cancer?
Depending on each case, treatment options for men with prostate cancer might include: Observation or Active Surveillance for Prostate Cancer. Surgery for Prostate Cancer. Radiation Therapy for Prostate Cancer. Cryotherapy for Prostate Cancer. Hormone Therapy for Prostate Cancer. Chemotherapy for Prostate Cancer.
What are the things to consider when making a decision about cancer treatment?
Some important things to consider include: The stage and grade of your cancer. Your age and expected life span.
Why do we do clinical trials?
Clinical trials are carefully controlled research studies that are done to get a closer look at promising new treatments or procedures . Clinical trials are one way to get state-of-the art cancer treatment. In some cases they may be the only way to get access to newer treatments. They are also the best way for doctors to learn better methods to treat cancer. Still, they're not right for everyone.
Why is it important to communicate with your cancer care team?
Communicating with your cancer care team is important so you understand your diagnosis, what treatment is recommended, and ways to maintain or improve your quality of life.
What do people with cancer need?
People with cancer need support and information, no matter what stage of illness they may be in. Knowing all of your options and finding the resources you need will help you make informed decisions about your care.
How to learn more about clinical trials?
If you would like to learn more about clinical trials that might be right for you, start by asking your doctor if your clinic or hospital conducts clinical trials.
What are the services offered by the American Cancer Society?
These might include nursing or social work services, financial aid, nutritional advice, rehab, or spiritual help. The American Cancer Society also has programs and services – including rides to treatment, lodging, and more – to help you get through treatment.
What is the stage of prostate cancer?
Prostate cancer is staged based on the extent (how much the cancer has spread) of the cancer (using T, N, and M categories) and the PSA level and Gleason score (Grade Group) when it is first diagnosed.
What to do if prostate cancer doesn't go away?
The options above are for the initial treatment of prostate cancer at different stages. But if these treatments aren’t working (the cancer continues to grow and spread) or if the cancer comes back, other treatments might be used, such as immunotherapy. (See Treating Prostate Cancer That Doesn’t Go Away or Comes Back After Treatment .)
What are the risk groups for cancer?
Risk groups range from very low risk to very high risk, with lower risk group cancers having a smaller chance of growing and spreading compared to those in higher risk groups. Other factors, such as your age, overall health, life expectancy, and personal preferences are also taken into account when looking at treatment options. ...
What are the treatment options for cancer?
Initial treatment options may include: Hormone therapy. Hormone therapy with chemotherapy. Hormone therapy with external beam radiation. Chemotherapy.
Can prostate cancer be treated with radiation?
For men without any prostate cancer symptoms who are elder ly and/or have other serious health problems that may limit their lifespan, observation or active surveillance is often recommended. For men who wish to start treatment, radiation therapy (external beam or brachytherapy) or radical prostatectomy may be options.
Can prostate cancer be seen on an imaging test?
This group of prostate cancers can be felt on exam or can be seen on an imaging test . The cancer might be found in more than half of one side of the prostate (cT2b) or in both sides of the prostate [cT2c], and/or have a grade group of 2 or 3 (Gleason score of 7) and/or a PSA level between 10 and 20 ng/ml. Additional classification criteria split the intermediate-risk group into favorable and unfavorable.
Does stage 2 prostate cancer grow outside the prostate?
Stage II cancers have not yet grown outside of the prostate, but are larger, have higher Gleason scores, and/or have higher PSA levels than stage I cancers. Stage II cancers that are not treated with surgery or radiation are more likely than stage I cancers to eventually spread beyond the prostate and cause symptoms.
How old do you have to be to get prostate cancer?
Age. As men age, their risk of getting prostate cancer goes up. It is rarely found in men younger than age 40 . Damage to the genetic material (DNA) of prostate cells is more likely for men over the age of 55. Damaged or abnormal prostate cells can begin to grow out of control and form tumors.
What happens when prostate cancer spreads?
After spreading, cancer cells may attach to other tissues and grow to form new tumors, causing damage where they land. When prostate cancer spreads from its original place to another part of the body, the new tumor has the same kind of abnormal cells and the same name as the primary (original) tumor.
Why is the PSA test important?
The PSA test and DRE are very important tools. They help to find prostate cancer early, before it spreads. When found early, it can be treated early which helps stop or slow the spread of cancer. This is likely to help some men live longer.
How long do men with prostate cancer live?
Today, 99% of men with prostate cancer will live for at least 5 years after diagnosis. Many men having treatment are cured. Most prostate cancer is slow-growing and takes many years to progress.
What is the job of the prostate and seminal vesicles?
It can disrupt the flow of urine from the bladder. The main job of the prostate and seminal vesicles is to make fluid to bathe semen. During ejaculation, sperm is made in the testicles, and then moves to the urethra. At the same time, fluid from the prostate and the seminal vesicles also moves into the urethra.
How does diet affect prostate cancer?
It isn't clear exactly how. Your risk may be higher if you eat more calories, animal fats, refined sugar and not enough fruits and vegetables. A lack of exercise is also linked to poor outcomes. Obesity (or being very overweight) is known to increase a man's risk of dying from prostate cancer. One way to decrease your risk is to lose weight, and keep it off.
Why is prostate cancer so high in Europe?
Higher rates may be due to better or more screening procedures, heredity, poor diets, lack of exercise habits, and environmental exposures.
Why is it important to know the stage of prostate cancer?
The information gathered from the staging process determines the stage of the disease. It is important to know the stage in order to plan treatment. The results of the tests used to diagnose prostate cancer are often also used to stage the disease. (See the General Information section .)
What are the signs of prostate cancer?
Signs of prostate cancer include a weak flow of urine or frequent urination. Tests that examine the prostate and blood are used to diagnose prostate cancer.
What is the purpose of a transrectal biopsy?
A biopsy is done to diagnose prostate cancer and find out the grade of the cancer (Gleason score). A transrectal biopsy is used to diagnose prostate cancer. A transrectal biopsy is the removal of tissue from the prostate by inserting a thin needle through the rectum and into the prostate.
What is the most common cancer in older men?
Anatomy of the male reproductive and urinary systems, showing the prostate, testicles, bladder, and other organs. Prostate cancer is most common in older men. In the U.S., about 1 out of 5 men will be diagnosed with prostate cancer.
How does cancer spread?
Cancer can spread through tissue, the lymph system, and the blood:
Why do cancer tests have to be repeated?
Some tests will be repeated in order to see how well the treatment is working. Decisions about whether to continue, change, or stop treatment may be based on the results of these tests.
How does chemo work?
Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. When chemotherapy is taken by mouth or injected into a vein or muscle, the drugs enter the bloodstream and can reach cancer cells throughout the body ( systemic chemotherapy ).
Who should talk to their doctor about prostate cancer?
Men who are at higher risk of prostate cancer – such as African-Americans or patients who have a family history of cancer – should talk to their doctors about any additional monitoring they should undergo, says Janet Farrar Worthington, who's co-written several books on prostate cancer.
How often do doctors do prostate MRIs?
For example, doctors at Johns Hopkins Hospital typically have a prostate cancer patient who's on active surveillance undergo an MRI every two to four years, Carter says.
What is the Gleason score for prostate cancer?
The grade is a way of determining the aggressiveness of the cancer on a scale known as the Gleason score. Gleason scores range from 6 to 10, with higher numbers indicating more aggressive cancer. "A Gleason score of 7 to 10 indicates a more aggressive cancer that is at higher risk of spreading than a Gleason 6 score," Simons says. "Patients should talk to their doctor about shared decision-making based on their biopsy results and other clinical factors, like your family history of cancer." Patients with a Gleason score of 6 or less should talk to their doctors about whether active surveillance is a viable option for them.
How many men have prostate cancer?
About 60% are diagnosed in men ages 65 or older, and the occurrence of prostate cancer in men younger than 40 is rare. Prostate cancer is the second-leading cause of cancer death among men in the U.S., trailing only lung cancer. About 1 in 9 men will be diagnosed with prostate cancer in his lifetime. Overall, more than 30% of men who are diagnosed ...
Is prostate cancer scary?
A diagnosis of prostate cancer can be understandably scary, but it's not a reason to panic, Carter says. It's crucial for men who are diagnosed with the disease to undergo the necessary tests to determine its aggressiveness, and to talk to their doctor to decide whether they need prostate cancer treatment.
Is radiation necessary for prostate cancer?
That means the cancer is basically lacking the ability to metastasize and become life-threatening, he says. Consequently, the typical treatments for prostate cancer – radiation or surgery to remove the prostate gland – aren't necessary, Simons says. [. See:
Can prostate cancer become aggressive?
For patients on active surveillance, the concern isn't that their prostate cancer will become more aggressive, he says. Rather, someone with low-level prostate cancer is at risk of having another, more aggressive form of prostate cancer develop. "We don't want to over-treat, and we don't want to miss a second, more aggressive cancer," he says.
Can you expect things to stay the same with cancer?
Don't expect things to stay the same. There will probably be changes in your close relationships as you adjust to living with cancer.
Do you need to read and digest prostate cancer?
You don't need to read and digest everything right now. Most men with the disease have time to figure things out. Many prostate tumors grow slowly, so you might not need to make decisions right away. Get help from your doctor to figure out what you need to know now and what can wait.
Can prostate cancer cause erections?
As prostate cancer treatments fight your disease, they can also cause other problems, like losing control of your bladder or trouble getting erections. Not all men will have these side effects, but you should talk about them with your doctor before you decide if and how you’ll treat your disease.
What is the treatment for prostate cancer?
Cryosurgery. Cryosurgery, or cryotherapy, is under evaluation for the treatment of localized prostate cancer. It is a surgical technique that involves destruction of prostate cancer cells by intermittent freezing of the prostate with cryoprobes, followed by thawing. [ 117] [.
What is the best follow up for prostate cancer?
The optimal follow-up strategy for men treated for prostate cancer is uncertain. Men should be interviewed and examined for symptoms or signs of recurrent or progressing disease, as well as side effects of therapy that can be managed by changes in therapy. However, using surrogate endpoints for clinical decision making is controversial, and the evidence that changing therapy based on such endpoints translates into clinical benefit is weak. Often, rates of PSA change are thought to be markers of tumor progression. However, even though a tumor marker or characteristic may be consistently associated with a high risk of prostate cancer progression or death, it may be a very poor predictor and of very limited utility in making therapeutic decisions.
What stage of cancer is considered definitive radiation therapy?
Candidates for definitive radiation therapy must have a confirmed pathologic diagnosis of cancer that is clinically confined to the prostate and/or surrounding tissues (stage I, stage II, and stage III). Staging laparotomy and lymph node dissection are not required.
How long does prostate cancer last?
If prostate cancer has spread to distant organs, current therapy will not cure it. Median survival is usually 1 to 3 years, and most of these patients will die of prostate cancer.
What is the most commonly used method to report tumor differentiation?
The most commonly used method to report tumor differentiation is the Gleason score. (Refer to the Pathology section of the General Information About Prostate Cancer section of this summary for more information.)
How many radical prostatectomies were performed in Sweden in the 1980s?
This occurred despite the use of watchful waiting or active surveillance or palliative hormonal treatment as the most common treatment strategies for localized prostate cancer during the entire era (<150 radical prostatectomies per year were performed in Sweden during the late 1980s).
What is the most common method of prostate biopsy?
Needle biopsy is the most common method used to diagnose prostate cancer. Most urologists now perform a transrectal biopsy using a bioptic gun with ultrasound guidance. Less frequently, a transperineal ultrasound-guided approach can be used in patients who may be at increased risk of complications from a transrectal approach. [ 25] Over the years, there has been a trend toward taking eight to ten or more biopsy samples from several areas of the prostate with a consequent increased yield of cancer detection after an elevated PSA blood test. [ 21]

Diagnosis
Treatment
Clinical Trials
Alternative Medicine
Preparing For Your Appointment
- Screening for prostate cancer
Testing healthy men with no symptoms for prostate cancer is controversial. There is some disagreement among medical organizations whether the benefits of testing outweigh the potential risks. Most medical organizations encourage men in their 50s to discuss the pros and …
Very-Low-Risk Group
- Your prostate cancer treatment options depend on several factors, such as how fast your cancer is growing, whether it has spread and your overall health, as well as the potential benefits or side effects of the treatment.
Low-Risk Group
- Explore Mayo Clinic studiestesting new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.
Intermediate-Risk Group
- No complementary or alternative treatments will cure prostate cancer. However, complementary and alternative prostate cancer treatments may help you cope with the side effects of cancer and its treatment. Nearly everyone diagnosed with cancer experiences some distress at some point. If you're distressed, you may feel sad, angry or anxious. You may experience difficulty sleeping or f…
High-Risk Group
- If you have signs or symptoms that worry you, start by seeing your family doctor. If your doctor suspects you may have a problem with your prostate, you may be referred to a urinary tract specialist (urologist). If you're diagnosed with prostate cancer, you may be referred to a cancer specialist (oncologist) or a specialist who uses radiation therapy to treat cancer (radiation oncol…
Very-High-Risk Group
Stage Iva
Stage Ivb