Precautions
Side effects requiring immediate medical attention
- Bloody nose
- bloody, black, or tarry stools
- vomiting of blood or material that looks like coffee grounds
What are side effects of clopidogrel?
Side effects requiring immediate medical attention
- Collection of blood under the skin
- deep, dark purple bruise
- itching, pain, redness, or swelling
What are the side effects of clopidogrel 75 mg?
Does clopidogrel affect blood pressure? Effects of Clopidogrel on Blood Pressure. Brief Summary: Arterial hypertension is associated with platelet activation, increased sCD40L levels and endothelial dysfunction suggesting that inhibition of platelet-derived sCD40L release may improve endothelial function and lower blood pressure (BP).
Does clopidogrel affect blood pressure?
Medications known to have serious interactions with clopidogrel oral. Brand Names Include: Plavix Oral. All generic drug interactions for clopidogrel oral (lists will include brand and generic names): 1 contraindicated drug interaction. 240 significant drug interactions. 11 minor drug interactions.
Does clopidogrel interact with other medications?
Do the side effects of clopidogrel go away?
Some side effects of clopidogrel may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
How long does clopidogrel take to wear off?
How long does clopidogrel (Plavix) stay in your body? The blood-thinning effect of clopidogrel (Plavix) can last for up to 5 days after your last dose. Keep this in mind if you're going to have surgery or any kind of procedure that might cause bleeding.
What is the most serious adverse effect of clopidogrel?
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
Do you need to wean off clopidogrel?
Abrupt cessation of clopidogrel results in an early rise in platelet aggregability in patients with BMS that is attenuated by a tapering regimen. Clopidogrel administration every other day may achieve similar levels of platelet inhibition as full dose therapy.
How long does it take to get blood thinners out of your system?
This depends on the type of blood thinner, and can range from hours to days. The blood thinning effects of warfarin, aspirin, and Plavix (clopidogrel) can last for days, whereas Eliquis (apixaban) and Xarelto (rivaroxaban) wear off in about a day. Lovenox (low molecular weight heparin) wears off after about 12 hours.
What are the most common side effects of clopidogrel?
Common side effects of clopidogrel can include:headaches or dizziness.nausea.diarrhoea or constipation.indigestion (dyspepsia)stomach ache or abdominal pain.nosebleeds.increased bleeding (your blood taking longer to clot – for example, when you cut yourself), or easy bruising.
What happens when you stop Plavix?
Patients who stop taking Plavix can develop clotting and could suffer a heart attack or stroke or other damage to their cardiovascular system. Patients coming off Plavix should be closely monitored by a doctor.
Does clopidogrel cause tiredness?
Clopidogrel may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: excessive tiredness. headache.
Is there a difference between clopidogrel and clopidogrel bisulfate?
Clopidogrel bisulfate (Plavix) is an anti-platelet drug, that is, a drug that inhibits the ability of platelets to clump together as part of a blood clot. Clopidogrel prevents blood clots by irreversibly binding to the P2Y12 receptor on platelets, preventing adenosine diphosphate (ADP) from activating platelets.
Can clopidogrel be stopped abruptly?
Do not stop taking clopidogrel without first talking to your health care professional. Suddenly stopping the use of antiplatelet medicines can put you at risk for heart attacks, strokes, and blood clots. Be aware that while taking clopidogrel you may bruise more easily, and it may take longer for any bleeding to stop.
Is it safe to stop clopidogrel after one year?
Contrary to some recent reports indicating a full 12 months of dual antiplatelet therapy following percutaneous coronary intervention (PCI) is unnecessary, a large Danish registry study shows that halting clopidogrel after 1 year raises the risk of death and reinfarction in myocardial infarction (MI) patients.
Can clopidogrel cause anxiety?
headache, fever, weakness, feeling tired; little or no urination; a seizure; low blood sugar--headache, hunger, sweating, irritability, dizziness, fast heart rate, and feeling anxious or shaky; or.
Before Taking This Medicine
You should not use clopidogrel if you are allergic to it, or if you have: 1. any active bleeding; or 2. a stomach ulcer or bleeding in the brain (s...
How Should I Take Clopidogrel?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use these medicines exactly as directed.Clop...
What Happens If I Miss A Dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What Happens If I Overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose can cause excessive bleeding.
What Should I Avoid While Taking Clopidogrel?
Avoid alcohol. It can increase your risk of stomach bleeding.Avoid activities that may increase your risk of bleeding or injury. Use extra care to...
Clopidogrel Dosing Information
Usual Adult Dose for Acute Coronary Syndrome:Unstable Angina (UA)/Non-ST-Elevation Myocardial Infarction (NSTEMI):-Loading dose: 300 mg orally once...
What Other Drugs Will Affect Clopidogrel?
Certain other medicines may increase your risk of bleeding, including aspirin. Avoid taking aspirin unless your doctor tells you to.Tell your docto...
What are the side effects of a syringe?
sweating. swelling of the eyes, face, or inside of the nose. swelling or inflammation of the mouth. swollen or painful glands. trouble breathing. unusual bleeding or bruising. watery or bloody diarrhea. yellow eyes or skin. Some side effects may occur that usually do not need medical attention.
What are the symptoms of a swollen eyelid?
nervousness. nightmares. noisy breathing. painful or difficult urination. pains in the side, possibly radiating to the back. pinpoint red spots on the skin. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. rash with flat lesions or small raised lesions on the skin. rectal bleeding.
Can medicine cause side effects?
Side Effects. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur:
If experienced, these tend to have a Severe expression i
Sorry, we have no data available. Please contact your doctor or pharmacist.
Are you currently using clopidogrel?
This survey is being conducted by the WebMD marketing sciences department.
What is clopidogrel used for?
Clopidogrel is used to lower your risk of having a stroke, blood clot, or serious heart problem after you've had a heart attack, severe chest pain ( angina ), or circulation problems. Clopidogrel may also be used for purposes not listed in this medication guide.
Can you breastfeed while taking Clopidogrel?
Tell your doctor if you are pregnant or plan to become pregnant. You should not breastfeed while using this medicine.
Can you take clopidogrel if you have a stomach ulcer?
You should not use clopidogrel if you have any active bleeding such as a stomach ulcer or bleeding in the brain. Clopidogrel increases your risk of bleeding, which can be severe or life-threatening.
Can you take Clopidogrel if you are allergic to it?
You should not use clopidogrel if you are allergic to it, or if you have: any active bleeding; or. a stomach ulcer or bleeding in the brain (such as from a head injury ). Tell your doctor if you have ever had: an ulcer in your stomach or intestines; or. a bleeding disorder or blood clotting disorder.
What enzyme is clopidogrel metabolized to?
Clopidogrel is metabolized to its active metabolite in part by CYP2C19. Concomitant use of drugs that inhibit the activity of this enzyme results in reduced plasma concentrations of the active metabolite of clopidogrel and a reduction in platelet inhibition.
What are the side effects of Plavix?
Common side effects of Plavix include diarrhea, rash, itching, abdominal pain, headache, chest pain, muscle aches, dizziness.
What is ticlid med?
dizziness. severe bleeding, allergic reactions, pancreatitis, and. liver failure. Ticlopidine (Ticlid) is an antiplatelet medication quite similar to clopidogrel. It has been associated with a severe reduction in white blood cell count in between 0.8% and 1% of persons.
What drugs interact with Plavix?
Drug interactions of Plavix include nonsteroidal anti-inflammatory drugs ( NSAIDs) such as ibuprofen, naproxen, diclofenac, etodolac, nabumetone, fenoprofen, flurbiprofen, indomethacin, ketoprofen, oxaprozin, piroxicam, sulindac, tolmetin, and mefenamic acid, because the combination may increase the risk of stomach and intestinal bleeding.
Is clopidogrel bisulfate a heart attack?
Plavix ( clopidogrel bisulfate) is an antiplatelet drug used to prevent strokes, heart attacks, and death in individuals who have had a previous stroke, unstable angina, heart attack or have peripheral arterial disease (PAD). The combination of Plavix and aspirin is better than aspirin or Plavix alone in preventing another heart attack but ...
Is clopidogrel a side effect of aspirin?
The risk of this dangerous side effect with clopidogrel is about 0.04%, much less than with ticlopidine but twice that of aspirin. Clopidogrel rarely causes a condition called thrombotic thrombocytopenic purpura (TTP) in one out of every 250,000 people.
Is plasmix the same as ticlopidine?
Plavix is similar to ticlopidine in chemical structure and in the way it works. Unlike ticlopidine, Plavix does not cause serious reductions of white cells in the blood and, therefore, routine blood testing to determine if the white blood cell count is low is not necessary during treatment.
What enzyme is used to increase the activity of clopidogrel?
Since clopidogrel is metabolized to its active metabolite partly by CYP2C19, use of drugs that induce the activity of this enzyme would be expected to result in increased drug levels of the active metabolite of clopidogrel.
What are the side effects of Plavix?
Common side effects of Plavix include: increased bleeding, nosebleeds, headaches, itching, and. bruising. Tell your doctor if you have serious side effects of Plavix including: bleeding that will not stop; bloody or tarry stools, blood in your urine;
How much Plavix should I take for ST elevation?
Plavix is supplied as 75 and 300 mg tablets. For acute coronary syndrome with a non-ST elevation MI, the initial recommended dose is 300 mg, followed by a 75 mg dose per day; for ST elevation MIs, the initial and continuing dose is 75 mg per day. The recommended dose is 75 mg per day for patient with a history of MI, stroke, or peripheral vascular disease. Many doctors may choose to add an aspirin per day along with the Plavix dose in both non-ST elevation and ST elevation MIs as well as to stroke and peripheral vascular disease patients.
Is clopidogrel a metabolite?
CYP2C19 Inhibitors. Clopidogrel is metabolized to its active metabolite in part by CYP2C19. Concomitant use of drugs that inhibit the activity of this enzyme results in reduced plasma concentrations of the active metabolite of clopidogrel and a reduction in platelet inhibition [see WARNINGS AND PRECAUTIONS ].
Does Plavix cause bleeding?
In CURE, Plavix use with aspirin was associated with an increase in major bleeding (primarily gastrointestinal and at puncture sites) compared to placebo with aspirin (see Table 1). The incidence of intracranial hemorrhage (0.1%) and fatal bleeding (0.2%) were the same in both groups. Other bleeding events that were reported more frequently in the clopidogrel group were epistaxis, hematuria, and bruise.
Does clopidogrel cause blood in urine?
Clopidogrel increases your risk of bleeding, which can be severe or life-threatening. Call your doctor or seek emergency medical attention if you have bleeding that will not stop, if you have blood in your urine, black or bloody stools, or if you cough up blood or vomit that looks like coffee grounds.
Is Plavix a CYP2C8 inhibitor?
Repaglinide (CYP2C8 Substrates) The acyl-β-glucuronide metabolite of clopidogrel is a strong inhibitor of CYP2C8. Plavix can increase the systemic exposure to drugs that are primarily cleared by CYP2C8, thereby needing dose adjustment and appropriate monitoring.
Query from Fiona Barton
Dr Healy, a friend suggested I email you. I am desperate to get some support with my story.
RxISK response
The first point to make is that the options are to agree that this is a withdrawal syndrome or else to disbelieve FB. For FB, the stakes are high, including death and significant disability. For the doctors there are no bad consequences of disbelieving her.
Solutions
It will need great skill to come up an answer. FB may need input from a haematologist rather than a cardiologist. In other cases of withdrawal, I advocate using liquid forms of a drug to wean off very slowly, but Clopidogrel permanently blocks some receptors and so this approach is of no use.
Clopidogrel – Plavix
It seemed to be by chance that the first post on this RxISK blog is on Clopidogrel. But maybe not.
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