Full Answer
What is the clinical experience with CoQ10 in cardiology?
The clinical experience in cardiology with CoQ10 includes studies on congestive heart failure, ischemic heart disease, hypertensive heart disease, diastolic dysfunction of the left ventricle, and reperfusion injury as it relates to coronary artery bypass graft surgery. The CoQ10-lowering effect of H …
Is coenzyme Q10 a breakthrough in the management of heart failure?
J Am Coll Cardiol 2008;52:1435–41. doi:10.1016/j.jacc.2008.07.044 . Coenzyme Q10: clinical benefits with biochemical correlates suggesting a scientific breakthrough in the management of chronic heart failure.
Is coenzyme Q10 therapeutic in dilated cardiomyopathy?
The authors have tried to study the therapeutic efficacy of coenzyme Q10 (CoQ10) in patients with dilated cardiomyopathy (DCM). In fact, CoQ10 has been shown to be deficient in myocardial tissue biopsies taken from DCM hearts, compared to normal hearts.
Does plasma coenzyme q10 (q10) concentration predict cardiovascular disease events?
Stocker R., Pollicino C., Gay C.A., et al. Neither plasma coenzyme Q10 concentration, nor its decline during pravastatin therapy, is linked to recurrent cardiovascular disease events: A prospective case-control study from the LIPID study.
Do heart doctors recommend CoQ10?
Heart conditions. CoQ10 has been shown to improve symptoms of congestive heart failure. Although findings are mixed, CoQ10 might help reduce blood pressure. Some research also suggests that when combined with other nutrients, CoQ10 might aid recovery in people who've had bypass and heart valve surgeries.
Does CoQ10 lower your heart rate?
Results: There were no significant differences in heart rate between the CoQ10 and placebo trials at rest or during exercise.
Does CoQ10 cause heart palpitations?
Research indicates that supplementing with CoQ10 or magnesium may provide palpitation relief in some individuals. One study investigating the effects of CoQ10 on heart failure found that 50 mg/day for 4 weeks led to a reduction in heart palpitations in participants.
Does CoQ10 interact with heart medication?
Coenzyme Q10 has no known severe, serious, or moderate interactions with other drugs. Mild interactions of Coenzyme Q10 include: atorvastatin. fluvastatin.
Who should not take CoQ10?
They include diarrhea, nausea, and heartburn. Risks. People with chronic diseases such as heart failure, liver problems, or diabetes should be wary of using this supplement. CoQ10 may lower blood sugar levels and blood pressure.
How much CoQ10 should I take for heart disease?
What's more, the supplement may reduce heart disease risk factors, such as by lowering “bad” LDL cholesterol ( 17 ). For people with heart failure or angina, the typical dosage recommendation for CoQ10 is 60–300 mg per day ( 18 ).
Which is better for heart CoQ10 or fish oil?
Both fish oil and CoQ10 are best known for their heart-healthy benefits. Fish oil naturally regulates the level of inflammation in your body, and it may help fight high levels of inflammation that are linked to cardiovascular disease.
What are the symptoms of low CoQ10?
What are the symptoms of CoQ10 deficiency? Whilst everyone is different, people who have a deficiency in CoQ10 levels often experience physical fatigue and muscle weakness, even while undertaking relatively non-strenuous physical activities such as walking.
What Vitamin stops heart palpitations?
Vitamin C. Arrhythmias and other heart conditions are associated with oxidant stress and inflammation. Antioxidants like vitamin C and vitamin E appear to be effective in reducing these.
Is CoQ10 safe to take with blood pressure medication?
Blood pressure medications: CoQ10 may work with blood pressure medications to lower blood pressure. In a clinical study of people taking blood pressure medications, adding CoQ10 supplements allowed them to reduce the doses of these medications.
Should heart failure patients take CoQ10?
Recently, long-term therapy with coenzyme Q10 (CoQ10) has been shown to improve heart failure symptoms, reduce major adverse cardiovascular events (MACE) and mortality, and to be safe and well tolerated.
Who should take CoQ10?
CoQ10 is found to be helpful in those with congestive heart failure, cardiomyopathy, neurologic disorders such as Parkinson's disease or Huntington's disease, dysfunctional mitochondria, high blood pressure, migraine headaches, and those who have had a recent heart attack.
What is CoQ10 in the mitochondria?
Coenzyme Q10 (CoQ10) is an endogenously synthesised and diet-supplied lipid-soluble cofactor that functions in the mitochondrial inner membrane to transfer electrons from complexes I and II to complex III . In addition, its redox activity enables CoQ10 to act as a membrane antioxidant. In patients with congestive heart failure, myocardial CoQ10 content tends to decline as the degree of heart failure worsens. A number of controlled pilot trials with supplemental CoQ10 in heart failure found improvements in functional parameters such as ejection fraction, stroke volume and cardiac output, without side effects. Subsequent meta-analyses have confirmed these findings, although the magnitude of benefit tends to be less notable in patients with severe heart failure, or within the context of ACE inhibitor therapy. The multicentre randomised placebo-controlled Q-SYMBIO trial has assessed the impact of supplemental CoQ10 on hard endpoints in heart failure. A total of 420 patients received either CoQ10 (100 mg three times daily) or placebo and were followed for 2 years. Although short-term functional endpoints were not statistically different in the two groups, CoQ10 significantly reduced the primary long-term endpoint—a major adverse cardiovascular event—which was observed in 15% of the treated participants compared to 26% of those receiving placebo (HR=0.50, CI 0.32 to 0.80, p=0.003). Particularly in light of the excellent tolerance and affordability of this natural physiological compound, supplemental CoQ10 has emerged as an attractive option in the management of heart failure, and merits evaluation in additional large studies.
Where is CoQ10 found?
CoQ10 is a key component in the mitochondrial ETC for ATP generation, and exists in abundance in the myocardium , as compared to other tissues. 18 Myocardial CoQ10 depletion has been postulated as a mechanism in development and progression of congestive heart failure (CHF).
Is CoQ10 water insoluble?
CoQ10, being water insoluble, is marketed in a variety of formulations that solubilise CoQ10 and facilitate its absorption. The commonly available preparations are in the forms of powder, tablets, softgel oil suspension capsules and two-piece capsules.
What causes heart failure?
Among a variety of causes, coronary artery disease, hypertension, cardiomyopathy, ageing, valvular heart disease and congenital heart disease are the most common. 1 Statistical data from the American Heart Association (AHA) show that a total of 5.1 million people in the USA suffer from heart failure, 2 while 23 million people have diagnosed heart failure worldwide. 3 Morbidity and mortality due to heart failure increase with age, 4 and it is reported that heart failure is responsible for one in nine deaths in the USA. 2 Moreover, heart failure is among the most frequent causes of hospitalisations and disability in the elderly. 5#N#,#N#6 Though there have been major improvements in pharmacological management of heart failure, mortality rates continue to exceed 10% per year, reaching between 20% to 50% in severe cases. 7
Does CoQ10 affect heart failure?
Early studies reported that myocardial levels of CoQ10 tended to decline with increasing severity of heart failure. Such a decline might be exacerbated by concurrent treatment with statins and β-blockers, which can suppress endogenous CoQ10 synthesis. Pilot supplementation trials with CoQ10 in HF patients reported improvements in functional parameters such as ejection fraction, stroke volume and cardiac output, with minimal side effects. These findings were reinforced by subsequent meta-analyses, which further concluded that benefits tended to be greater in earlier stage HF and in patients not treated with ACEIs. Moreover, it was found that in-hospital plasma CoQ10 in HF patients correlated inversely with subsequent mortality. Most definitively, the very recent Q-SYMBIO trial, a multicentre randomised placebo-controlled trial, has demonstrated the beneficial impact of supplemental CoQ10 on hard end points in HF. Thus, in aggregate, evidence suggests that supplemental CoQ10 may be a useful option for effective management of heart failure, with the advantage of excellent clinical tolerance—reflecting its status as an essential physiological cofactor.
Is CoQ10 good for statins?
Another possible benefit of CoQ10 supplementation may be its ability to improve exercise capacity in those treated with statins. 70 As exercise capacity is a strong predictor of prognosis, this might be another advantage of CoQ10 supplementation. 71.
Does CoQ10 help with HF?
There have been numerous observational reports in the last few decades reporting the usefulness of CoQ10 in improving HF symptoms, including ejection fraction, left ventricular size and quality of life. However, these studies had several design shortcomings, which have prevented their translation into clinical practice. 46–53
What is the purpose of CoQ10?
Overview. Coenzyme Q10 (CoQ10) is an antioxidant that your body produces naturally. Your cells use CoQ10 for growth and maintenance. Levels of CoQ10 in your body decrease as you age.
What is CoQ10 supplement?
CoQ10 dietary supplements are available as capsules, chewable tablets, liquid syrups, wafers and by IV. CoQ10 might help prevent or treat certain heart conditions, as well as migraine headaches.
Does CoQ10 help with Parkinson's?
Recent research suggests that even high doses of CoQ10 don't seem to improve symptoms in people with Parkinson's disease. Statin-induced myopathy. Some research suggests that CoQ10 might help ease the muscle weakness and pain sometimes associated with taking statins. Migraines.
Does CoQ10 help with heart failure?
Heart conditions. CoQ10 has been shown to improve symptoms of congestive heart failure. Although findings are mixed, CoQ10 might help reduce blood pressure. Some research also suggests that when combined with other nutrients, CoQ10 might aid recovery in people who've had bypass and heart valve surgeries.
What is the medical term for dietary selenium deficiency?
In Asia and Africa, dietary selenium deficiency is associated with a cardiomyopathy known as Keshan disease and an osteoarthropathy called Kashin-Beck disease.
What is the name of the disease that was discovered in the 1930s?
Selenium Deficiency and Cardiomyopathy. In the 1930’s selenium deficiency cardiomyopathy was reported in children living in the Keshan province of China, “Keshan’s Disease”. (36-38) Researchers discovered the cardiomyopathy could be reversed by administering selenium supplements to the children.
What is the CoQ10 supplement?
This looked like a good case for a trial of CoQ-10, a cardiac supplement made popular by Stephen T. Sinatra’s 1999 book, CoQ10 and the Heart . Stephen T. Sinatra’s later wrote, Metabolic Cardiology, about the combination of Co-Q10, D-Ribose and L-Carnitine. The daughter gave her dad the CoQ-10 by “sneaking” it into his food. She opened the CoQ10 capsules and mixed it into her dad’s food, 300 mg per day. Three weeks later her dad was well enough to leave the hospital and go home, an obvious case of success with CoQ-10.
What is white marble disease?
In the 1950’s University of Oregon researchers identified white marble disease in cattle, a form of muscle degeneration in cattle grazing on selenium deficient soils. The pattern of muscle degeneration resembles the human disease.
How long was the old man in congestive heart failure?
The old man had been in congestive heart failure on the third floor for six weeks with ischemic cardiomyopathy caused by accumulation of small areas of heart damage (infarction) from underlying coronary artery disease. His ejection fraction was quite low (20%), indicating reduced pumping ability of the heart.
When did Andrea Frustaci report her findings?
Dr Andrea Frustaci reported in 1999 her landmark study of biopsy sampling of the myocardium in 13 patients with cardiomyopathy. (2,3) Dr Andrea Frustaci found massive accumulation (22,000 times normal) of heavy metals in the myocardium in these patients, and speculated this adversely affects mitochondrial function:
Is CoQ10 reversible?
These data suggest that the CoQ10 deficiency in DCM may be reversible and that the therapeutic effects depend on the basal plasmatic and myocardial levels.
What is the term for the thickening of the left ventricle?
“Hypertrophic cardiomyopathy (HCM) is manifested by severe thickening of the left ventricle with significant diastolic dysfunction. Previous observations on the improvement in diastolic function and left ventricular wall thickness through the therapeutic administration of coenzyme Q10 (CoQ10) in patients with hypertensive heart disease prompted the investigation of its utility in HCM.
What is the condition where the heart is thickened?
“ Hypertrophic cardiomyopathy ( HCM) is a condition in which a portion of the heart becomes thickened without an obvious cause. This results in the heart being less able to pump blood effectively. Symptoms vary from none to feeling tired, leg swelling, and shortness of breath. It may also result in chest pain or fainting. Complications include heart failure, an irregular heartbeat, and sudden cardiac death.
What classification system is used for heart failure?
The table below describes the most commonly used classification system, the New York Heart Association (NYHA) Functional Classification1. It places patients in one of four categories based on how much they are limited during physical activity…”
