What is the WHO recommended treatment protocol for TB?
The preferred regimen for treating adults with TB remains a regimen consisting of an intensive phase of 2 months of isoniazid (INH), rifampin (RIF), pyrazinamide (PZA), and ethambutol (EMB) followed by a continuation phase of 4 months of INH and RIF.
How do you manage tuberculosis?
If you have an active TB disease you will probably be treated with a combination of antibacterial medications for a period of six to 12 months. The most common treatment for active TB is isoniazid INH in combination with three other drugs—rifampin, pyrazinamide and ethambutol.
What method monitors the effectiveness of the treatment regimen for TB?
The use of sputum smear microscopy and culture rather than sputum smear microscopy alone is recommended for the monitoring of patients with multidrug-resistant TB (MDR-TB) during treatment (conditional recommendation/very low quality evidence) (2).
Why is multiple drug therapy used for tuberculosis?
When two or more drugs to which in vitro susceptibility has been demonstrated are given together, each helps prevent the emergence of tubercle bacilli resistant to the others. The standard of care for initiating treatment of TB disease is four-drug therapy.
What is the first-line treatment for TB?
First-line agents for treatment of active TB consist of isoniazid, a rifamycin (rifampin or [less frequently] either rifapentine or rifabutin), pyrazinamide, and ethambutol; in addition, moxifloxacin is a first-line agent when administered in combination with isoniazid, rifapentine, and pyrazinamide [6].
What is tuberculosis and its management?
Tuberculosis (TB) is a contagious infection that usually attacks your lungs. It can also spread to other parts of your body, like your brain and spine. A type of bacteria called Mycobacterium tuberculosis causes it.
What should a TB patient monitor?
New pulmonary TB patients with positive sputum smears at the start of treatment. These patients should be monitored by sputum smear microscopy at the end of the fifth and sixth months. If results at the fifth or sixth month are positive, a sputum specimen should be obtained for culture and DST.
Which among the following is used in the treatment of tuberculosis?
The most common medications used to treat tuberculosis include: Isoniazid. Rifampin (Rifadin, Rimactane) Ethambutol (Myambutol)
Which drug is included in all TB treatment regimens?
Of the approved drugs, the first-line anti-TB agents that form the core of treatment regimens are:isoniazid (INH),rifampin (RIF),ethambutol (EMB), and.pyrazinamide (PZA).
Is Penicillin a treatment for TB?
Unfortunately, penicillin seemed to have minimal if any effect on M. tuberculosis (14). However, its great success had inspired Selman Waksman at Rutgers University to probe an extensive repository of soil microbes that he had accumulated in his agricultural research for microbes with antibiotic properties.
What is multidrug therapy?
Leprosy. Leprosy is curable with a combination of drugs known as multidrug therapy (MDT), as the treatment of leprosy with only one antileprosy drug (monotherapy) will result in development of drug resistance to that drug. The combination of drugs used in the MDT depends on the classification of the disease.