How is TLS treated?
In general, treatment of TLS consists of intensive hydration, stimulation of diuresis, and, more specifically, in the use of allopurinol and rasburicase.Feb 2, 2017
What is TLS medicine?
Tumor lysis syndrome (TLS) is a condition that occurs when a large number of cancer cells die within a short period, releasing their contents in to the blood.May 10, 2018
How do you manage tumor lysis syndrome?
Conventional management of TLS consists of aggressive intravenous hydration, diuretic therapy, urinary alkalization, and inhibition of urate production by high-dose allopurinol.
What nursing intervention will help prevent complications from tumor lysis syndrome that may occur during chemotherapy?
Nursing interventions should include monitoring of urine output and alkalinization, when sodium bicarbonate is used. Any decrease in output should be reported; diuretics should be given and/or intravenous fluids should be adjusted accordingly.Apr 23, 2006
What is TLS prevention?
The most important treatment for TLS is prevention. The mainstays of TLS prevention include aggressive hydration, control of hyperuricemia with allopurinol and rasburicase treatment, and close monitoring of electrolyte abnormalities.
What is TLS prophylaxis?
TLS monitoring & prophylaxis: The best way to manage this condition is to identify it early on (before a patient develops TLS clinical manifestations) and prevent its clinical consequences by employing an effective preventive regimen (considerations include intravenous crystalloid administration, allopurinol ...
How does allopurinol help with TLS?
Allopurinol. Allopurinol is a key agent in the management of TLS. Allopurinol acts by competitively inhibiting xanthine oxidase, thereby preventing the conversion of xanthine to uric acid. When used for treatment, allopurinol is used in dosages similar to prophylactic dosages.Apr 14, 2011
What do you monitor for TLS?
Patients with TLS should generally receive continuous cardiac monitoring as well as measurement of electrolytes and uric acid every 4 to 6 hours (Larson & Pui, 2012b). Treatment is aimed at reversing the electrolyte derangements as well as treating the acute kidney injury.Mar 1, 2013
What drugs cause TLS?
Agents reported to cause tumor lysis syndrome include the following:Paclitaxel.Fludarabine.Etoposide.Thalidomide.Bortezomib.Zoledronic acid.Hydroxyurea.Carfilzomib.More items...
How does allopurinol prevent tumor lysis syndrome?
Medications can be adjusted after the start of chemotherapy in response to the level of tumor lysis and/or metabolic disturbances. Allopurinol, a xanthine oxidase inhibitor, reduces the conversion of nucleic acid byproducts to uric acid, in this way preventing urate nephropathy and subsequent oliguric renal failure.Dec 22, 2020
Which of the following is a strategy to prevent tumor lysis syndrome for a patient that is at intermediate risk?
hydration is the key prevention strategy for all patients at low, intermediate, or high risk for TLS. Hydration, and the subsequent increase in urinary output, minimizes the risk of uric acid or calcium phosphate precipitation in the renal tubules.Jul 1, 2016
What oncology nurses need to know about tumor lysis syndrome?
Description. Tumor lysis syndrome (TLS) is an oncologic emergency caused by massive tumor cell death with the release of large amounts of potassium, phosphate, and nucleic acids into systemic circulation. Nucleic acids break down to uric acid, leading to hyperuricemia in patients.Oct 2, 2018